Background Intrahepatic cholangiocarcinoma (ICC) is a highly aggressive tumor of the bile duct, and a significant public health problem in East Asia, where it is associated with infection by the parasiteOpisthorchis viverrini. ICC is often detected at an advanced stage and with a poor prognosis, making a biomarker for early detection a priority. Methods We have comprehensively profiled miRNA expression levels in ICC tumor tissue using small RNA-Seq and validated these profiles using quantitative PCR on matched plasma samples. Results Distinct miRNA profiles were associated with increasing histological differentiation of ICC tumor tissue. We also observed that histologically normal tissue adjacent to ICC tumor displayed miRNA expression pr...
Accumulating evidence has demonstrated that microRNAs (miRNAs or miRs) play an important role in the...
Background: Cholangiocarcinoma (CCA) has an abundance of tumor stroma which plays an important role ...
Biliary tract cancer (BTC) is often difficult to diagnose definitively, even through histological ex...
Background: Intrahepatic cholangiocarcinoma (ICC) is a highly aggressive tumor of the bile duct, and...
Intrahepatic cholangiocarcinoma (ICC) is an aggressive cancer, arising in the biliary ducts that ext...
Background & Aims: Intrahepatic cholangiocarcinoma (ICC) is a significant public health problem in E...
AbstractIntrahepatic cholangiocarcinoma (ICC) is an aggressive cancer, arising in the biliary ducts ...
BACKGROUND: Although many studies have confirmed a relationship between microRNAs (miRNAs) and chola...
Background: Although many studies have confirmed a relationship between microRNAs (miRNAs) and chola...
The diagnosis of primary sclerosing cholangitis (PSC) is difficult due to the lack of sensitive and ...
Bile-duct cancers (BDC) are a group of solid tumors arising from the biliary tree. Despite their cla...
AbstractBackgroundMicroRNAs (miRNAs) are small non‐coding genes which become dysregulated in cancer ...
Pancreatic ductal adenocarcinoma (PDAC) and biliary tract cancers (BTC) are lethal diseases and have...
The diagnosis of primary sclerosing cholangitis (PSC) is difficult due to the lack of sensitive and ...
Patients with primary sclerosing cholangitis (PSC) are at high risk for the development of cholangio...
Accumulating evidence has demonstrated that microRNAs (miRNAs or miRs) play an important role in the...
Background: Cholangiocarcinoma (CCA) has an abundance of tumor stroma which plays an important role ...
Biliary tract cancer (BTC) is often difficult to diagnose definitively, even through histological ex...
Background: Intrahepatic cholangiocarcinoma (ICC) is a highly aggressive tumor of the bile duct, and...
Intrahepatic cholangiocarcinoma (ICC) is an aggressive cancer, arising in the biliary ducts that ext...
Background & Aims: Intrahepatic cholangiocarcinoma (ICC) is a significant public health problem in E...
AbstractIntrahepatic cholangiocarcinoma (ICC) is an aggressive cancer, arising in the biliary ducts ...
BACKGROUND: Although many studies have confirmed a relationship between microRNAs (miRNAs) and chola...
Background: Although many studies have confirmed a relationship between microRNAs (miRNAs) and chola...
The diagnosis of primary sclerosing cholangitis (PSC) is difficult due to the lack of sensitive and ...
Bile-duct cancers (BDC) are a group of solid tumors arising from the biliary tree. Despite their cla...
AbstractBackgroundMicroRNAs (miRNAs) are small non‐coding genes which become dysregulated in cancer ...
Pancreatic ductal adenocarcinoma (PDAC) and biliary tract cancers (BTC) are lethal diseases and have...
The diagnosis of primary sclerosing cholangitis (PSC) is difficult due to the lack of sensitive and ...
Patients with primary sclerosing cholangitis (PSC) are at high risk for the development of cholangio...
Accumulating evidence has demonstrated that microRNAs (miRNAs or miRs) play an important role in the...
Background: Cholangiocarcinoma (CCA) has an abundance of tumor stroma which plays an important role ...
Biliary tract cancer (BTC) is often difficult to diagnose definitively, even through histological ex...