Antipyretic Activity of Hydroalcoholic Extract of Dactylorhiza Hatagirea Roots & Lavandula Stoechas Flowers on Brewer’s Yeast Induced Pyrexia in Wistar Rats

Medicinal plants are the part and parcel of human society to combat against different diseases from the dawn of human civilization. According to World Health Organization, approximately 85% population of the developing countries are facing difficulties to afford synthetic drugs and are relying on traditional medicines mainly of plant origin in order to maintain their primary health care needs. Plants are being used in various disorders. The present pharmacological investigation was undertaken to study the anti-pyretic activity of hydroalcoholic extract of D. hatagirea roots (HEDH) & L. stoechas flowers (HELS) in albino rats against yeast induced pyrexia. Hydroalcoholic extract of D. hatagirea roots & L. stoechas flowers (5, 50, 300 and 2000 mg/ kg) orally to observe acute toxicity, and observed for 14 days. Eight groups of six animals were used for the experiment. The yeast induced pyrexia method was standardized first by injecting 15% yeast suspension (s.c) followed by recording the rectal temperature at regular intervals. Then the evaluation of anti-pyretic activity of hydroalcoholic extract of D. hatagirea roots & L. stoechas flowers (100, 200mg/kg & 300mg/kg) was carried out by using this standard procedure. The extract of D. hatagirea & L. stoechas plant showed a significant (P<0.01) dose dependent antipyretic effect in yeast induced elevation of body temperature in experimental rats. The data generated during study shows that D. hatagirea roots & L. stoechas flowers having significant anti-pyretic activity. Keywords: Dactylorhiza Hatagirea, Lavandula Stoechas, Anti-pyretic activity, Yeast induced pyrexi