THE ANTIDIABETIC AND ANTIOXIDANT ACTIVITY OF COCCINEA GRANDIS VOIGT STEM EXTRACT IN STREPTOZOTOCIN INDUCED DIABETIC RATS

Objective: In the present study, the antidiabetic and antioxidant study of stem part of Coccinea grandis Voigt plant extracts in Streptozotocin induced diabetic rats were investigated. Materials and methods: Fifty four Wistar albino rats were used with nine groups and with six rats in each group. 45 mg/kg body weight streptozotocin was administered to group 2 to 9. Group 2 was diabetic control. Group 3 was given with glimepiride as standard drug. Group 4 and 5 were given petroleum ether extract 250 and 500 mg/kg respectively. Group 6 and 7 were given 250 and 500 mg/kg chloroform extract respectively. Group 8 and 9 were given 250 and 500 mg/kg hydro alcoholic extract respectively. Antidiabetic activity of the extracts was assessed by serum glucose level on glucose kit. Superoxide dismutase (SOD), Catalase (CAT) and lipid peroxidation studies were assessed with histopathology. Result: The chronic study data on diabetic rats cleared the administration of all extracts significantly reduced blood glucose level and lipid peroxidation level with better antioxidant activity. Conclusion: From the study, the petroleum ether, chloroform and hydro alcoholic extracts of stem part of Coccinea grandis Voigt plant have shown antidiabetic and antioxidant potential. Key Words: Antidiabetic activity, antioxidant activity, Lipid peroxidation, Superoxide dismutase, Catalase