Mania and bipolar illness are the major problems in the schizophrenia treatment, zotepine, atypical antipsychotic drug used for this condition. The aim of present investigation was to develop mucoadhesive microemulsion of zotepine for intranasal delivery by phase titration method. The developed formulations were evaluated for its size, zeta, PDI and invitro release studied. The optimized formulation, containing 5% Oleic acid, 40% Tween 80: PEG400 (3:1) and 55% water. The globule size (53.1±0.31), zeta potential (-32.1±0.2),PDI (0.13±0.23).0.5% chitosan was added to the optimized formulation to prepare mucoadhesive formulation. Keywords: Zotepine; Microemulsion; pseudoternary phase diagram; solubility
Clozapine is the most effective antipsychotic for treatment-resistant schizophrenia. However, it cau...
WOS: 000399500700007PubMed ID: 26738443The purpose of the current research was to prepare and evalua...
ABSTRACT: Nasal cavity has used as alternative route for the drugs with poor water solubility, susce...
The purpose of our study was to improve the solubility, bioavailability, and efficacy of zotepine (Z...
The purpose of our study was to improve the solubility, bioavailability, and efficacy of zotepine (Z...
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Objective: The present work is aimed at developing liquid self-nanoemulsifying drug delivery system ...
AbstractIntranasal drug administration is receiving increased attention as a delivery method for byp...
The objective of the present study was to develop and evaluate mucoadhesive dosage form of Domperido...
Blood brain barrier, poor solubility and low bioavailability (<27%) due to hepatic metabolism are...
The purpose of the present study was to formulate and characterize carbamazepine loaded microemulsio...
Objective: The current investigation objective was to fabricate gastroretentive mucoadhesive microsp...
Introduction: The purpose of this article was to design a bilayer floating- drug delivery system usi...
Clozapine is the most effective antipsychotic for treatment-resistant schizophrenia. However, it cau...
WOS: 000399500700007PubMed ID: 26738443The purpose of the current research was to prepare and evalua...
ABSTRACT: Nasal cavity has used as alternative route for the drugs with poor water solubility, susce...
The purpose of our study was to improve the solubility, bioavailability, and efficacy of zotepine (Z...
The purpose of our study was to improve the solubility, bioavailability, and efficacy of zotepine (Z...
The purpose of this study was to develop and optimize microemulsion containing agomelatine for intra...
Objective: The objective of this research was to formulate and evaluate olanzapine (OLE) mucoadhesiv...
AbstractThe purpose of the present study was to formulate and characterize carbamazepine loaded micr...
Objective: The present work is aimed at developing liquid self-nanoemulsifying drug delivery system ...
AbstractIntranasal drug administration is receiving increased attention as a delivery method for byp...
The objective of the present study was to develop and evaluate mucoadhesive dosage form of Domperido...
Blood brain barrier, poor solubility and low bioavailability (<27%) due to hepatic metabolism are...
The purpose of the present study was to formulate and characterize carbamazepine loaded microemulsio...
Objective: The current investigation objective was to fabricate gastroretentive mucoadhesive microsp...
Introduction: The purpose of this article was to design a bilayer floating- drug delivery system usi...
Clozapine is the most effective antipsychotic for treatment-resistant schizophrenia. However, it cau...
WOS: 000399500700007PubMed ID: 26738443The purpose of the current research was to prepare and evalua...
ABSTRACT: Nasal cavity has used as alternative route for the drugs with poor water solubility, susce...