Acute Toxicity Studies and In-vitro Antioxidant Potential of Solanum indicum

Solanum indicum (Solanaceae) is traditionally used treatment of cough, asthma, sexual disorders and diarrhoea. Efficacy of traditional medicine was determined using the in-vitro antioxidant activity of the plant extract. Toxicological codicil of the drug was performed following OECD guidelines 423 with slight modifications. Solanum indicum extract administered to the rats by oral gavage at 500, 1000, 1500 & 2000 mg/kg body weight daily up to 28 days to male and female Sprague Dawley rats. Oral toxicity studies substantiate, no treatment-related death or toxic indicia were observed. It revealed that the Solanum indicum extract could be well tolerated up to the dose 2000 mg/kg body weight and could be classified as Category 5 drug.) Keywords: Solanum indicum, Phytochemistry, Antioxidant, Acute toxicity, DPPH, H2O