Preparation and evaluation of sulfamethoxazole solid dispersion employing starch citrate-a new solubility enhancer

Sulfamethoxazole used widely as a broad spectrum antibiotic. However, its solubility and dissolution rate is very low due to poor solubility in water. Solid dispersion technique was selected for the current research to improve solubility and drug absorption from of Sulfamethoxazole. A new solubility enhancer starch citrate was selected prepared and characterized for its solubility, viscosity, swelling index, gelling property, particle size, etc. Prepared Sulfamethoxazole solid dispersion was evaluated for drug content and in vitro dissolution. Keywords: Sulfamethoxazole, Starch citrate, Solid dispersion & In vitro study