Anti-hyperglycemic & Anti-hyperlipidemic Activity of Leaves of Centella asiatica Linn. in Diabetic Rats

Aim- The main aim of the study is to evaluate the Antidiabetic and antihyperlipidemic activity of Centella asiatica in diabetic animals. Material & Methods- Different extracts were prepared by successive solvent extraction methods. Diabetes was induced by single injection of STZ in normal animals and diabetes was confirmed by glucose oxidation methods. The treatments of different extracts were given from third day to 21st day and at the end of 22nd day, blood sample was withdrawn and different lipid level was determined.  Result- Among all the extracts, dichloromethane extracts showed significantly activity in reducing blood glucose level and decreased the VLDL, LDL, TC, Triglycerides and significantly increased the HDL-C level. Conclusion- The results obtained in this study have shown that dichloromethane extract shown significant Antidiabetic and antihyperlipidemic activity. Further detailed studies are required to isolate the active phytoconstituents by bioactivity guided isolation techniques responsible for anti-diabetic and hypolipidemic activity. The present findings are significant for the development of alternative, inexpensive and safer therapy for the treatment of diabetes mellitus and hyperlipidemic. Keywords: Hyperlipidemia, STZ induced diabetes, Centella asiatica, VLDL-C, LDL-