A COMPARATIVE STUDY ON MONOTHERAPY AND COMBINATION THERAPY OF PANTOPRAZOLE WITH PREGABALIN AGAINST SURGICAL ESOPHAGITIS

The objective of this study was to evaluate the effect of pantoprazole and pregabalin on experimental esophagitis in albino rats. The groups of rats fasted for 24 hours and were subjected to pylorus and forestomach ligation. Rats of different groups received normal saline (3 ml/kg, po; sham control), pantoprazole (30 mg/kg, po), pregabalin (30 mg/kg, po) and their combinations along with a parallel toxic control group. Animals were sacrificed after 8 h and evaluated for the gastric pH, total acidity, free acidity and esophagitis index. The morphological changes were scrutinized by digital microscopy. The beneficial effect of pantoprazole and pregabalin against GERD could be attributed to the anti-secretory action of pantoprazole and reduction in the tracheal lower esophageal sphincter release rate by pregabalin. Combination therapy of gamma-aminobutyric acid derivative promotes proton pump inhibitor based healing of reflux esophagitis in animal model. Keywords: Esophagitis, Pantoprazole, Pregabalin, Pylorus ligation, Gamma-aminobutyric acid