DEVELOPMENT OF CLARITHROMYCIN GASTRORETENTIVE MICROSPHERES

Gastroretentive microspheres of clarithromycin were prepared on the principle of cation induced gelification using sodium alginate and pectin. These microspheres were investigated for micromeritic properties, drug entrapment, mucoadhesion and drug release properties. Microspheres were found to be discrete, spherical and free flowing. Microspheres were found to adhere to gastric mucosa with high affinity and showed controlled drug release