SUPERCRITICAL FLUID TECHNOLOGY: AN INNOVATIVE APPROACH USED TO ENHANCE SOLUBILITY OF WATER INSOLUBLE DRUGS

Certain techniques are used for the preparation of solid dispersions and used to enhance the solubility of water insoluble drugs. One of its techniques is supercritical fluid technology that is used for the preparation of solid dispersions. The present aim of this technique is to provide the recent advances in the use of supercritical fluids for the preparation of solid dispersion and for pharmaceutical substances with particular attention to drug delivery systems. Basically, a “supercritical fluid†can be defined as it enters in the pure substance when both temp. & pressure above its critical P&T. In the SCF techniques, there are certain solvents like CO2, N2O used as the supercritical fluid. This innovative technique is highly promising and approachable for the future applications in pharmaceutical industries. Keywords: Supercritical fluids, solubility, solid dispersion, drug delivery, and Applications