NOVEL FORMULATION STRATEGIES FOR INSULIN DELIVERY

Insulin is a hormone made by the pancreas that allows your body to use sugar (glucose) from carbohydrates in the food that you eat for energy or to store glucose for future use. Successful oral insulin delivery involves overcoming the enzymatic and physical barriers. Several companies across the globe are developing oral insulin based on different technology platforms. Insulin has been encapsulated in nanoparticles by mucoadhesive polymers such as chitosan, poly (lacticco-glycolic acid) (PLGA), and alginate which prevent enzymatic degradation and allow absorption across the epithelial layer in Peyer’s patches. Keywords: Novel Formulation Strategies, Insulin, hyperglycemia, Nanosphere-based oral insulin deliver