FORMULATION AND EVALUATION OF IN-SITU NASAL GEL OF RIZATRIPTAN BENZOATE BY USING MUCOADHESIVE POLYMERS

Rizatriptan Benzoate undergo hepatic first pass metabolism. Aim of present research work is to improve bioavailability by formulating in-situ nasal gel. Formulation was developed to decrease the mucociliary authorization by using mucoadhesive polymer in gel, thus rising the contact time with nasal mucosa and humanizing the absorption of drug. Gels were primed by cold technique process and evaluate by Appearance, Viscosity, Gelation Temperature, Permeation Studies, Drug Content, Gel strength etc.. The gelation temperature of all studied gel formulations were found in range. Drug release was initiated in between 68.8-94.7% with K-peppas best fit model. pH of gel was in the rang and drug content was found between 92-99.89 %. Gel strength was found in range of 20-55 sec. Keywords: Rizatriptan Benzoate, Mucociliary, Strength Â