FORMULATION AND EVALUATION OF PIROXICAM FAST DISSOLVING TABLETS USING DIFFERENT NATURAL SUPERDISINTEGRANTS

The demand for fast dissolving tablets has been growing during the last decade, especially for geriatric and pediatric patients who have swallowing rapidly. Piroxicam is a potent anti-inflammatory drug used in treatment of osteoarthritis, rheumatoid arthritis, ankylosing Spondylitis and acute gout disease. In the present work, 9 formulations of fast dissolving Tablets of Piroxicam (F1 to F9) were prepared using three different Superdisintegrants namely isapghula, fenugreek and guar gum with three concentrations (4%, 5% and 6%) and a control F10 (without superdisintegrant) by direct compression method. The final blend of the drug and excipients were evaluated for powder flow properties, bulk density, tapped density, compressibility index and hausner’s ratio. All the formulations were evaluated for thickness, weight variation, disintegration time, hardness, friability. Formulation F7 showed the lowest disintegration time. In-vitro dissolution studies revealed that formulation F4 showed 99.18 % percent drug release at the end of 60 minutes. Keywords: Anti-inflammatory, Direct compression, fast dissolving, Piroxicam,     Superdisintegran