EVALUATION OF ANALGESIC ACTIVITY OF ROOTS OF PICRORHIZA KURROA

Methodology:-The selected drug from the authentic literature is in form of dried roots of Picrohiza kurroa belonging to family scrophulariaceae. Analgesic activity of root powder is extracted with alcohol for 7 days. The extracts in these dose levels of 250 mg/kg, 500 mg/kg were tested. The analgesic activity was studied by using the Hot plate and Acetic acid induced-writhing method in albino mice of either sex. The writhing are measured within 10 min. Results:- The 500mg/kg drug of picrorhiza kurroa having similar effect to the standard drug pentazocin at ½ hrs.pentazocin is agonist-antagonist type of analgesic drug.in hot plate method the 500mg/ kg drug of picrorhiza kurroa is effective at the ½ hrs than the 250mg/ kg Conclusions:-Dose effective of ethanolic extract of picrorhiza kurroa 500 mg/kg. by Hot   plate method and Acetic acid induced writhing method