A large body of clinical evidence suggests that viral infections in the periphery can exacerbate neurodegenerative conditions such as Alzheimer\u27s disease, Huntington\u27s, disease, Parkinson\u27s disease, multiple sclerosis, and seizures. The underlying mechanisms of these conditions involve the activation of the acute phase response (APR), part of the innate immune system, which recognizes viral molecular patterns. As neighboring cells become infected, inflammatory mediators are released into the bloodstream and relayed to the central nervous system where they produce a mirror inflammatory response. To induce the APR, polyinosinic-polycytidylic acid (PIC), a viral mimetic, is commonly used. PIC produces a robust and transient increase...
Astrocytes remove glutamate from the synaptic cleft via specific transporters, and impaired glutamat...
Tumor necrosis factor (TNF)-alpha is a proinflammatory cytokine acting on two distinct receptor subt...
THESIS 8906Excitotoxicity is implicated as a mechanism of neuronal cell death in a range of neurodeg...
A large body of clinical evidence suggests that viral infections in the periphery can exacerbate neu...
Peripheral viral infections increase seizure propensity and intensity in susceptible individuals. We...
Peripheral infections increase the propensity and severity of seizures in susceptible populations. W...
We have previously shown that peripherally restricted acute phase response (APR) elicited by intrape...
It has been well established that peripheral inflammation resulting from microbial infections profou...
Seizure syndromes are common neuropathologies associated with epilepsy, metabolic disturbances, stro...
Anti-NMDA receptor and anti-AMPA receptor (NMDAR and AMPAR) encephalitides are debilitating but reve...
Peripheral viral infections are potent comorbid factors that exacerbate neurodegeneration. Althou...
PURPOSE: Early-life seizures increase vulnerability to subsequent neurologic insult. We tested the h...
Influenza A virus (IAV) causes respiratory tract disease and is responsible for seasonal and reoccur...
During the last decade, experimental research has demonstrated a prominent role of glial cells, acti...
The central nervous system (CNS) can be the target for several infections that include those with RN...
Astrocytes remove glutamate from the synaptic cleft via specific transporters, and impaired glutamat...
Tumor necrosis factor (TNF)-alpha is a proinflammatory cytokine acting on two distinct receptor subt...
THESIS 8906Excitotoxicity is implicated as a mechanism of neuronal cell death in a range of neurodeg...
A large body of clinical evidence suggests that viral infections in the periphery can exacerbate neu...
Peripheral viral infections increase seizure propensity and intensity in susceptible individuals. We...
Peripheral infections increase the propensity and severity of seizures in susceptible populations. W...
We have previously shown that peripherally restricted acute phase response (APR) elicited by intrape...
It has been well established that peripheral inflammation resulting from microbial infections profou...
Seizure syndromes are common neuropathologies associated with epilepsy, metabolic disturbances, stro...
Anti-NMDA receptor and anti-AMPA receptor (NMDAR and AMPAR) encephalitides are debilitating but reve...
Peripheral viral infections are potent comorbid factors that exacerbate neurodegeneration. Althou...
PURPOSE: Early-life seizures increase vulnerability to subsequent neurologic insult. We tested the h...
Influenza A virus (IAV) causes respiratory tract disease and is responsible for seasonal and reoccur...
During the last decade, experimental research has demonstrated a prominent role of glial cells, acti...
The central nervous system (CNS) can be the target for several infections that include those with RN...
Astrocytes remove glutamate from the synaptic cleft via specific transporters, and impaired glutamat...
Tumor necrosis factor (TNF)-alpha is a proinflammatory cytokine acting on two distinct receptor subt...
THESIS 8906Excitotoxicity is implicated as a mechanism of neuronal cell death in a range of neurodeg...