Novel bisstyryl derivatives of bakuchiol: Targeting oral cavity pathogens

Novel bisstyryl derivatives of bakuchiol using Heck coupling reaction as the key step were synthesized and screened against a panel of six oral cavity pathogens for their antimicrobial activity. Four compounds (9e12) showed two to fourfold and four to eightfold better activity (MIC 0.25e16 mg/ml)than bakuchiol and triclosan respectively. These compounds effectively inhibit the biofilm formation of single and multiple species at 2 e 8 � MICs. 4- and 40-Hydroxy/methoxy styryl moieties of the bakuchiol derivatives play a pivotal role towards the activity as established in the SAR studies.Mechanism of action studies revealed microbial membrane structure disruption as the probable mode of action of these compounds