Improved synthesis of pyrrolo[1,2-c]pyrimidine and derivatives

An improved synthesis of pyrrolo[1,2-c]pyrimidine derivatives by cyclocondensation of pyrrole-2-carboxaldehydes with tosylmethyl isocyanide followed by desulfonylation of the resulting 2-tosylpyrrolo[1,2-c]pyrimidines with sodium amalgam is described.We thank the Comissió Interdepartamental de Reserca i Innovació Tecnológica (CIRIT) for financial support (project QFN91-4619 ) and the Ministerio de Educación y Ciencia for a grant (J.M.M.