Correlation of IL-10 with CD4^+CD25^+ T Regulatory Cells Acting on Effector T Cells

P(論文)Regulatory T (Treg) cells can suppress effector T cells, but the mechanism underlying its suppression function is not comprehended. Here we examine the inhibiting co-stimulating molecule CTLA4 and cytokines secreted by Treg cells, and explore the immunology mechanism of T regulatory cells acting on effector T cells in co-cultured system (CCS) and separating-cultured system (SCS). Compared with effector T cells, Treg cells expressed higher level CTLA4 and secreted much more IL-10 and TGF-β_1 (P<0.01). The inhibitory capacity of Treg cells co-cultured with effector T cells is much stronger than that in separating cultured group (P<0.01). Moreover, the inhibiting rate of Treg cells exerting on effector T cells through secreting IL-10 was more powerful than that through secreting TGF-β_1 (P