Pengaruh Pemberian secara Subkronik Minyak Atsiri Daun Sirsak (Annona muricata Linn.) terhadap Kadar Low Density Lipoprotein (LDL) dan High Density Lipoprotein (HDL) Serum Tikus Wistar

Introduction: The essential oil of soursop (Annona muricata Linn.) leaves contains terpenoid, alkaloid, and phenolic compounds. Terpenoid, alkaloid and phenolic function as antioxidants and antiinflammatory agents appropriately. When used in high concentrations and in long period, it may become toxic, which mayincreasein LDL and decrease in HDL. The study is to determine the safety of soursopleaf essential oil on LDL and HDL levels in wistar rats.Methods: This was an invivo experimental study with a control group post test only design using 20 male and 20 female wistar rats divided into 8 groups, consisting of KN (tween 80), P1 (1,25 mg/kgBW), P2 (2,5 mg/kgBW), and P3 (5mg/kgBW) both male and female rats. This study was conducted for 28 days then the LDL and HDL levels were checked after the treatment. Results were analized using One Way ANOVA test followed by Least Significant Difference (LSD). Results are assumed significant if p