The antibiotic action of the ionophore valinomycin is a result of its ability to preferentially bind potassium ions and transport them across cellular membranes. Complexation is solely due to the molecular structure of this cyclic depsipeptide. In solution, the molecule exists in different conformers depending upon solvent polarity. Exact knowledge as to the structure of valinomycin in the aqueous and lipid cellular layers is thus difficult to determine. Many spectral studies of valinomycin have been undertaken utilizing a variety of instrumental methods and conformations existing in different solvents have been proposed. We have performed energy minimization procedures on these structures. Conformations were generated both with and without...
This study demonstrates how the intramolecular nuclear Overhauser effect (NOE) experiment can be emp...
We investigated the complexation of valinomycin (VM) in different solvent environments with the aid ...
We used synchrotron radiation to measure the K-edge absorption spectra of the potassium ion in valin...
Valinomycin is a highly flexible cyclic dodecadepsipeptide that transports ions across membranes. Su...
Knowledge of the molecular mechanisms involved in ionophore-mediated cation transport would be valua...
Valinomycin is a potent ionophore known for its ability to transport potassium ions across biologica...
The electrostatic potential of valinomycin in various conformations as obtained by the crystal struc...
Conformations of valinomycin and its complexes with Perchlorate and thiocyanate salts of barium, in...
As a step to increasing the reliability of the calculation of free energies underlying ion binding a...
The structure of valinomycin in a range of organic solvents of varying polarity and in detergent and...
The conformation of the ionophore antibiotic valinomycin in its barium perchlorate complex has been ...
The mechanism of ion transport by carrier ionophores is investigated. The electrostatic potential is...
The solution conformations of complexes of valinomycin with magnesium and strontium were investigate...
The natural antibiotic valinomycin is of great interest due to the high complexation selectivity it ...
Molecular dynamics simulations of kalinomycin (VM) and its potassium complex in water and in a Lenna...
This study demonstrates how the intramolecular nuclear Overhauser effect (NOE) experiment can be emp...
We investigated the complexation of valinomycin (VM) in different solvent environments with the aid ...
We used synchrotron radiation to measure the K-edge absorption spectra of the potassium ion in valin...
Valinomycin is a highly flexible cyclic dodecadepsipeptide that transports ions across membranes. Su...
Knowledge of the molecular mechanisms involved in ionophore-mediated cation transport would be valua...
Valinomycin is a potent ionophore known for its ability to transport potassium ions across biologica...
The electrostatic potential of valinomycin in various conformations as obtained by the crystal struc...
Conformations of valinomycin and its complexes with Perchlorate and thiocyanate salts of barium, in...
As a step to increasing the reliability of the calculation of free energies underlying ion binding a...
The structure of valinomycin in a range of organic solvents of varying polarity and in detergent and...
The conformation of the ionophore antibiotic valinomycin in its barium perchlorate complex has been ...
The mechanism of ion transport by carrier ionophores is investigated. The electrostatic potential is...
The solution conformations of complexes of valinomycin with magnesium and strontium were investigate...
The natural antibiotic valinomycin is of great interest due to the high complexation selectivity it ...
Molecular dynamics simulations of kalinomycin (VM) and its potassium complex in water and in a Lenna...
This study demonstrates how the intramolecular nuclear Overhauser effect (NOE) experiment can be emp...
We investigated the complexation of valinomycin (VM) in different solvent environments with the aid ...
We used synchrotron radiation to measure the K-edge absorption spectra of the potassium ion in valin...