Congenital heart disease is the number one cause of birth defects in the United States, affecting approximately 40,000 newborns each year. Research has shown that serious structural defects of the heart can occur due to abnormal looping. Looping refers to the positional and morphological changes of the early embryo heart and is divided into different phases. Although progress has been made in identifying the genetic processes behind heart looping, the forces involved with the developmental process are still not fully understood. In this research, the chicken embryo heart was used as the experimental model and certain material properties were characterized. The Atomic Force Microscope was used to measure tissue stiffness at various locations...
Heart development, especially the critical phase of cardiac looping, is a complex and intricate proc...
Background: Hemodynamics, forces from the flowing blood in the heart, is a major epigenetic factor f...
This thesis addresses the questions of when and how mechanical stiffness arises during embryonic hea...
AbstractCardiac looping is a vital morphogenetic process that transforms the initially straight hear...
Research on fetal cardiac looping is an important because cardiac looping is the first organ to unde...
For decades, biologists have worked to identify many of the genetic and molecular factors involved i...
The heart is the first functioning organ to form in the embryo. For decades, biologists have worked ...
During embryonic development, changes in the cardiovascular microstructure and material properties a...
Abstract—Looping is a vital event during early cardiac morpho-genesis, as the initially straight hea...
<p>Congenital heart disease (CHD) has the highest incidence and mortality rate of all birth defects ...
Due to the character of the original source materials and the nature of batch digitization, quality ...
R esearchers in Cornell's Department of Biomedical Engineering are generat-ing a better underst...
The heart is the first organ that starts to function in a developing embryo. It continues to undergo...
During developmental stages, biomechanical stimuli on cardiac cells modulate genetic programs, and d...
The early embryonic heart is a tubular structure that forms by merging of left and right heart field...
Heart development, especially the critical phase of cardiac looping, is a complex and intricate proc...
Background: Hemodynamics, forces from the flowing blood in the heart, is a major epigenetic factor f...
This thesis addresses the questions of when and how mechanical stiffness arises during embryonic hea...
AbstractCardiac looping is a vital morphogenetic process that transforms the initially straight hear...
Research on fetal cardiac looping is an important because cardiac looping is the first organ to unde...
For decades, biologists have worked to identify many of the genetic and molecular factors involved i...
The heart is the first functioning organ to form in the embryo. For decades, biologists have worked ...
During embryonic development, changes in the cardiovascular microstructure and material properties a...
Abstract—Looping is a vital event during early cardiac morpho-genesis, as the initially straight hea...
<p>Congenital heart disease (CHD) has the highest incidence and mortality rate of all birth defects ...
Due to the character of the original source materials and the nature of batch digitization, quality ...
R esearchers in Cornell's Department of Biomedical Engineering are generat-ing a better underst...
The heart is the first organ that starts to function in a developing embryo. It continues to undergo...
During developmental stages, biomechanical stimuli on cardiac cells modulate genetic programs, and d...
The early embryonic heart is a tubular structure that forms by merging of left and right heart field...
Heart development, especially the critical phase of cardiac looping, is a complex and intricate proc...
Background: Hemodynamics, forces from the flowing blood in the heart, is a major epigenetic factor f...
This thesis addresses the questions of when and how mechanical stiffness arises during embryonic hea...