Aberrant epidermal growth factor receptor (EGFR) signaling is widespread in cancer, making the EGFR an important target for therapy. EGFR gene amplification and mutation are common in glioblastoma (GBM), but EGFR inhibition has not been effective in treating this tumor. Here we propose that primary resistance to EGFR inhibition in glioma cells results from a rapid compensatory response to EGFR inhibition that mediates cell survival. We show that in glioma cells expressing either EGFR wild type or the mutant EGFRvIII, EGFR inhibition triggers a rapid adaptive response driven by increased tumor necrosis factor (TNF) secretion, which leads to activation in turn of c-Jun N-terminal kinase (JNK), the Axl receptor tyrosine kinase and extracellula...
Abstract In glioblastoma (GBM), heterogeneous expression of amplified and mutated epidermal growth ...
Intratumoral heterogeneity contributes to cancer drug resistance, but the underlying mechanisms are ...
Glioblastoma Multiforme (GBM) is an aggressive brain tumor for which there is no cure. Overexpressio...
Aberrant epidermal growth factor receptor (EGFR) signaling is widespread in cancer, making the EGFR ...
Epidermal growth factor receptor (EGFR) is highly amplified, mutated and overexpressed in human mali...
AbstractEpidermal growth factor receptor (EGFR) signaling is strongly implicated in glioblastoma (GB...
Glioblastoma (GBM) is the most aggressive form of adult brain cancer with a 5-year survival rate of ...
Epidermal growth factor receptor (EGFR) gene amplification and activating mutations are common findi...
Epidermal growth factor (EGF) receptor (EGFR) is commonly amplified and/or mutated in high-grade gli...
Targeted therapy against driver mutations responsible for cancer progression has been shown to be ef...
Intratumoral heterogeneity contributes to cancer drug resistance, but the underlying mechanisms are ...
Grade IV glioblastoma is characterized by increased kinase activity of epidermal growth factor recep...
Targeted therapy against driver mutations responsible for cancer progression has been shown to be ef...
Epidermal growth factor receptor (EGFR) signaling is strongly implicated in glioblastoma (GBM) tumor...
Glioblastoma is a particularly resilient cancer, and while therapies may be able to reach the brain ...
Abstract In glioblastoma (GBM), heterogeneous expression of amplified and mutated epidermal growth ...
Intratumoral heterogeneity contributes to cancer drug resistance, but the underlying mechanisms are ...
Glioblastoma Multiforme (GBM) is an aggressive brain tumor for which there is no cure. Overexpressio...
Aberrant epidermal growth factor receptor (EGFR) signaling is widespread in cancer, making the EGFR ...
Epidermal growth factor receptor (EGFR) is highly amplified, mutated and overexpressed in human mali...
AbstractEpidermal growth factor receptor (EGFR) signaling is strongly implicated in glioblastoma (GB...
Glioblastoma (GBM) is the most aggressive form of adult brain cancer with a 5-year survival rate of ...
Epidermal growth factor receptor (EGFR) gene amplification and activating mutations are common findi...
Epidermal growth factor (EGF) receptor (EGFR) is commonly amplified and/or mutated in high-grade gli...
Targeted therapy against driver mutations responsible for cancer progression has been shown to be ef...
Intratumoral heterogeneity contributes to cancer drug resistance, but the underlying mechanisms are ...
Grade IV glioblastoma is characterized by increased kinase activity of epidermal growth factor recep...
Targeted therapy against driver mutations responsible for cancer progression has been shown to be ef...
Epidermal growth factor receptor (EGFR) signaling is strongly implicated in glioblastoma (GBM) tumor...
Glioblastoma is a particularly resilient cancer, and while therapies may be able to reach the brain ...
Abstract In glioblastoma (GBM), heterogeneous expression of amplified and mutated epidermal growth ...
Intratumoral heterogeneity contributes to cancer drug resistance, but the underlying mechanisms are ...
Glioblastoma Multiforme (GBM) is an aggressive brain tumor for which there is no cure. Overexpressio...