Add to ORKGThe efficacy of cancer immunotherapy is limited, in part, by the multitude of immunosuppressive mechanisms present within the tumor microenvironment (TME). Galectin-3 (Gal-3) is a lectin that contributes to TME immunosuppression and regulates diverse functions including cellular homeostasis and cancer biology. Increased Gal-3 expression during cancer progression augments tumor growth, invasiveness, metastatic potential, and immune suppression, which highlights the potential use of Gal-3 as a therapeutic target capable of modulating anti-tumor immunity. Here, we discuss the mechanisms by which Gal-3 regulates lymphocytes, the role of Gal-3 in lung and prostate tumors, and the contribution of Gal-3 to TME immunosuppression
BACKGROUND: Galectin-3 is a 31 kD carbohydrate-binding lectin that is over-expressed by many human m...
Evasion of immune surveillance is an accepted hallmark of tumor progression. The production of immun...
Galectins are glycan-binding proteins implicated in intracellular signaling, cell-cell communication...
The efficacy of cancer immunotherapy is limited, in part, by the multitude of immunosuppressive mech...
International audienceGalectin-3 (Gal3) is a multifaceted protein which belongs to a family of lecti...
peer reviewedGalectin-3, a multifunctional lectin, is involved during cancer progression. Previous o...
Galectin-3 is a β-galactoside binding lectin expressed in tumour cells and macrophages and has been...
Abstract Background Immunologic factors can promote the progression of oral squamous cell carcinomas...
Galectins constitute an evolutionary conserved family that binds to β-galactosides. There is growing...
Abstract Background Neck dissection is standard in surgical management of oral squamous cell carcino...
A combination therapy approach is required to improve tumor immune infiltration and patient response...
Galectin-3, a β galactoside-binding lectin, plays an important role in the processes relevant to tum...
Galectin-3, a member of the beta-galactoside-binding lectin family, is involved in a variety of biol...
Galectin-3 (Gal-3) is a member of the family of β-galactoside-binding mammalian lectins known as gal...
Abstract\ud \ud Background\ud Galectin-3 is a multifun...
BACKGROUND: Galectin-3 is a 31 kD carbohydrate-binding lectin that is over-expressed by many human m...
Evasion of immune surveillance is an accepted hallmark of tumor progression. The production of immun...
Galectins are glycan-binding proteins implicated in intracellular signaling, cell-cell communication...
The efficacy of cancer immunotherapy is limited, in part, by the multitude of immunosuppressive mech...
International audienceGalectin-3 (Gal3) is a multifaceted protein which belongs to a family of lecti...
peer reviewedGalectin-3, a multifunctional lectin, is involved during cancer progression. Previous o...
Galectin-3 is a β-galactoside binding lectin expressed in tumour cells and macrophages and has been...
Abstract Background Immunologic factors can promote the progression of oral squamous cell carcinomas...
Galectins constitute an evolutionary conserved family that binds to β-galactosides. There is growing...
Abstract Background Neck dissection is standard in surgical management of oral squamous cell carcino...
A combination therapy approach is required to improve tumor immune infiltration and patient response...
Galectin-3, a β galactoside-binding lectin, plays an important role in the processes relevant to tum...
Galectin-3, a member of the beta-galactoside-binding lectin family, is involved in a variety of biol...
Galectin-3 (Gal-3) is a member of the family of β-galactoside-binding mammalian lectins known as gal...
Abstract\ud \ud Background\ud Galectin-3 is a multifun...
BACKGROUND: Galectin-3 is a 31 kD carbohydrate-binding lectin that is over-expressed by many human m...
Evasion of immune surveillance is an accepted hallmark of tumor progression. The production of immun...
Galectins are glycan-binding proteins implicated in intracellular signaling, cell-cell communication...