Small molecules that target microtubules (MTs) represent promising therapeutics to treat certain types of cancer, including glioblastoma multiform (GBM). We synthesized modified carbazoles and evaluated their antitumor activity in GBM cells in culture. Modified carbazoles with an ethyl moiety linked to the nitrogen of the carbazole and a carbonyl moiety linked to distinct biaromatic rings exhibited remarkably different killing activities in human GBM cell lines and patient-derived GBM cells, with I
Carbazole comprises an important class of heterocycles. Carbazole is a tricyclic molecule having a c...
Microtubules, composed of alpha beta tubulin dimers, are dynamic polymers of eukaryotic cells. They ...
The carbazole class is made up of heterocyclically structured compounds first isolated from coal ta...
Chemotherapeutics used in cancer treatment may elicit pleiotropic effects interfering, for instance,...
Cancer is one of the leading chronic diseases with a high mortality rate worldwide. Current statist...
Paclitaxel is a microtubule stabilizing agent and a successful drug for cancer chemotherapy inducing...
Breast cancer is still considered a high-incidence disease, and numerous are the research efforts fo...
Carbendazim (methyl 2-benzimidazolecarbamate) is widely used as a systemic fungicide in human food p...
Over the years, carbazoles have been largely studied for their numerous biological properties, inclu...
Both carbazole and thiosemicarbazide scaffold showed various potential biological activities in medi...
Nocodazole is an antineoplastic agent that exerts its effects by depolymerizing microtubules. Herein...
Carbazole moiety is an important scaffold with a variety of biological applications, for example, an...
Nocodazole is an antineoplastic agent that exerts its effects by depolymerizing microtubules. Herein...
<div><p>Increased death rates due to lung cancer have necessitated the search for potential novel an...
Increased death rates due to lung cancer have necessitated the search for potential novel anticancer...
Carbazole comprises an important class of heterocycles. Carbazole is a tricyclic molecule having a c...
Microtubules, composed of alpha beta tubulin dimers, are dynamic polymers of eukaryotic cells. They ...
The carbazole class is made up of heterocyclically structured compounds first isolated from coal ta...
Chemotherapeutics used in cancer treatment may elicit pleiotropic effects interfering, for instance,...
Cancer is one of the leading chronic diseases with a high mortality rate worldwide. Current statist...
Paclitaxel is a microtubule stabilizing agent and a successful drug for cancer chemotherapy inducing...
Breast cancer is still considered a high-incidence disease, and numerous are the research efforts fo...
Carbendazim (methyl 2-benzimidazolecarbamate) is widely used as a systemic fungicide in human food p...
Over the years, carbazoles have been largely studied for their numerous biological properties, inclu...
Both carbazole and thiosemicarbazide scaffold showed various potential biological activities in medi...
Nocodazole is an antineoplastic agent that exerts its effects by depolymerizing microtubules. Herein...
Carbazole moiety is an important scaffold with a variety of biological applications, for example, an...
Nocodazole is an antineoplastic agent that exerts its effects by depolymerizing microtubules. Herein...
<div><p>Increased death rates due to lung cancer have necessitated the search for potential novel an...
Increased death rates due to lung cancer have necessitated the search for potential novel anticancer...
Carbazole comprises an important class of heterocycles. Carbazole is a tricyclic molecule having a c...
Microtubules, composed of alpha beta tubulin dimers, are dynamic polymers of eukaryotic cells. They ...
The carbazole class is made up of heterocyclically structured compounds first isolated from coal ta...