Add to ORKGThe current algorithm for Lynch syndrome diagnosis is highly complex with multiple steps which can result in an extended time to diagnosis while depleting precious tumor specimens. Here we describe the analytical validation of a custom probe-based NGS tumor panel, TumorNext-Lynch-MMR, which generates a comprehensive genetic profile of both germline and somatic mutations that can accelerate and streamline the time to diagnosis and preserve specimen. TumorNext-Lynch-MMR can detect single nucleotide variants, small insertions and deletions in 39 genes that are frequently mutated in Lynch syndrome and colorectal cancer. Moreover, the panel provides microsatellite instability status and detects loss of heterozygosity in the five Lynch genes
Both incidence and mortality of colorectal cancer (CRC) in Romania have shown a continuous increase ...
Germline defects of mismatch repair (MMR) genes underlie Lynch Syndrome (LS). We aimed to gain compr...
Approximately 1-2% of colorectal cancers (CRC) arise because of germline mutations in UNA mismatch r...
The current algorithm for Lynch syndrome diagnosis is highly complex with multiple steps which can r...
The development of the new technologies such as the next-generation sequencing (NGS) makes more acce...
Background: Sensitive and reliable molecular diagnostics is needed to guide therapeutic decisions fo...
Lynch syndrome (LS) is caused by germline mutations in DNA mismatch repair (MMR) genes and is the mo...
Lynch syndrome (LS) is the most common hereditary cancer syndrome. Early diagnosis improves prognosi...
Introduction: Colorectal carcinomas are the second most common cancer in the Netherlands. Approximat...
Lynch syndrome (LS) is an autosomal dominant disorder that predisposes to colon, endometrial, and ot...
BackgroundInactivating mutations in the MLH1 DNA mismatch repair (MMR) gene underlie 42% of Lynch sy...
Since 2017, the National Institute for Health and Care Excellence (NICE) has recommended molecular t...
PURPOSE: Microsatellite instability (MSI) testing of colorectal cancer tumors is used as a screening...
Tumor testing of colorectal cancers (CRC) for mismatch repair (MMR) deficiency is an effective appro...
Microsatellite instability (MSI) is used to screen colorectal cancers (CRC) for Lynch Syndrome, and ...
Both incidence and mortality of colorectal cancer (CRC) in Romania have shown a continuous increase ...
Germline defects of mismatch repair (MMR) genes underlie Lynch Syndrome (LS). We aimed to gain compr...
Approximately 1-2% of colorectal cancers (CRC) arise because of germline mutations in UNA mismatch r...
The current algorithm for Lynch syndrome diagnosis is highly complex with multiple steps which can r...
The development of the new technologies such as the next-generation sequencing (NGS) makes more acce...
Background: Sensitive and reliable molecular diagnostics is needed to guide therapeutic decisions fo...
Lynch syndrome (LS) is caused by germline mutations in DNA mismatch repair (MMR) genes and is the mo...
Lynch syndrome (LS) is the most common hereditary cancer syndrome. Early diagnosis improves prognosi...
Introduction: Colorectal carcinomas are the second most common cancer in the Netherlands. Approximat...
Lynch syndrome (LS) is an autosomal dominant disorder that predisposes to colon, endometrial, and ot...
BackgroundInactivating mutations in the MLH1 DNA mismatch repair (MMR) gene underlie 42% of Lynch sy...
Since 2017, the National Institute for Health and Care Excellence (NICE) has recommended molecular t...
PURPOSE: Microsatellite instability (MSI) testing of colorectal cancer tumors is used as a screening...
Tumor testing of colorectal cancers (CRC) for mismatch repair (MMR) deficiency is an effective appro...
Microsatellite instability (MSI) is used to screen colorectal cancers (CRC) for Lynch Syndrome, and ...
Both incidence and mortality of colorectal cancer (CRC) in Romania have shown a continuous increase ...
Germline defects of mismatch repair (MMR) genes underlie Lynch Syndrome (LS). We aimed to gain compr...
Approximately 1-2% of colorectal cancers (CRC) arise because of germline mutations in UNA mismatch r...