Takotsubo Cardiomyopathy and Acquired Long-QT Syndrome

A 55-year-old woman developed acute myocardial infarction while grieving for the death of her pet. The initial ECG showed T-wave inversion in leads I, aVL, V2, and V3, and a corrected QT (QTc) interval of 529 ms. Cardiac enzymes were mildly elevated. Cardiac catheterization revealed normal coronary arteries with akinesis of the anterior wall with ballooning during systole, findings compatible with an atypical form of Takotsubo cardiomyopathy. The patient responded to medical therapy. The second day, the QTc interval was reduced to 476 ms and then gradually normalized. Echocardiography at 7 days showed complete resolution of the anterior wall motion abnormalities