Нитрозивный стресс и растворимые дифференцировочные молекулы при обострении хронической обструктивной болезни легких

Summary. The aim of this study was to investigate nitrite blood levels (NO2 –) and the total nitrite and nitrate concentration (Σ NO2 – / NO3 –) in the exhaled breath condensate (EBC) and to evaluate interrelationships between NO metabolites and serum sCD50, sCD54, sHLA-I, sCD95 soluble differentiation molecules in patients with exacerbation of chronic obstructive pulmonary disease (COPD). We examined 110 patients with exacerbation of COPD stages I–III and 28 healthy non-smokers. Exacerbation of COPD stages II and III was found to be related to a significant increase in NO2 level in the blood and (Σ NO2 – / NO3 –) in EBC, increased concentrations of sCD50, sCD54, sHLA-I molecules and decreased concentration of sCD95 molecules. Statistically significant strong relationships were found between nitrous stress parameters and serum concentrations of soluble differentiation molecules in exacerbation of COPD. These data could indicate a role of soluble sCD50, sCD54, sHLA-I, sCD95 molecules and nitrous stress in the pathogenesis of COPD progression. These biomarkers could be used as predictors of poor prognosis of early-stage COPD and as diagnostic criteria of exacerbation of COPD stages II–III