Cell-permeable biphenols, such as honokiol, present in herbal teas, inhibit autonomic responses. The effects of biphenols on calcium signaling activated by human M3 muscarinic receptors was studied in Chinese hamster ovary (CHO) cells. Receptor binding was determined by radiolabelled ligand binding; intracellular calcium concentrations were determined using a fura-2 ratiometric imaging protocol; cytotoxicity was determined using a dye reduction assay. Activation of M3 muscarinic receptors with carbachol induced a biphasic increase in [Ca2+]i: an initial, IP3- mediated release of Ca2+ from endoplasmic reticulum stores followed by a sustained phase of steady Ca2+ entry (i.e., store operated calcium entry, SOCE). Biphneols had potent (EC50 ≈ μ...
Muscarine acetylcholine receptors were characterized in NB-OK1 cells using radioligand (H-3-NMS) bin...
Xanomeline is an agonist endowed with functional preference for M1/M4 muscarinic acetylcholine recep...
AbstractThe m2 and m3 muscarinic acetylcholine receptors were expressed in CHO cells and were shown ...
Honokiol, a cell-permeable phenolic compound derived from the bark of magnolia trees, inhibits multi...
Background: Honokiol, a cell-permeable phenolic compound derived from the bark of magnolia trees and...
Asian herbal medicine has used plants to treat many diseases for years. Two main compounds derived f...
Gallein is a large cyclic carbon molecule with multiple functional groups. With no known medical use...
Purpose: Metabotropic receptor agonists that signal through Gq-coupled pathways increase Ca2+ in mam...
1. Otilonium bromide (OB) is a smooth muscle relaxant used in the treatment of irritable bowel syndr...
The effect of NO on calcium oscillations elicited by low concentrations of a muscarinic agonist in C...
Depletion of internal Ca*+ stores causes capacitative Ca*’ entry which occurs through non-selective ...
Muscarinic acetylcholine receptors play important role in many physiological and pathophysiological ...
International audienceWe investigated the acute effect of low concentrations of BPA on calcium influ...
S-nitrosoglutathion (SNG) is a well known smooth muscle relaxant and a nitric oxide donor when intro...
The human population is regularly exposed to bisphenols. The first compound of this class, bisphenol...
Muscarine acetylcholine receptors were characterized in NB-OK1 cells using radioligand (H-3-NMS) bin...
Xanomeline is an agonist endowed with functional preference for M1/M4 muscarinic acetylcholine recep...
AbstractThe m2 and m3 muscarinic acetylcholine receptors were expressed in CHO cells and were shown ...
Honokiol, a cell-permeable phenolic compound derived from the bark of magnolia trees, inhibits multi...
Background: Honokiol, a cell-permeable phenolic compound derived from the bark of magnolia trees and...
Asian herbal medicine has used plants to treat many diseases for years. Two main compounds derived f...
Gallein is a large cyclic carbon molecule with multiple functional groups. With no known medical use...
Purpose: Metabotropic receptor agonists that signal through Gq-coupled pathways increase Ca2+ in mam...
1. Otilonium bromide (OB) is a smooth muscle relaxant used in the treatment of irritable bowel syndr...
The effect of NO on calcium oscillations elicited by low concentrations of a muscarinic agonist in C...
Depletion of internal Ca*+ stores causes capacitative Ca*’ entry which occurs through non-selective ...
Muscarinic acetylcholine receptors play important role in many physiological and pathophysiological ...
International audienceWe investigated the acute effect of low concentrations of BPA on calcium influ...
S-nitrosoglutathion (SNG) is a well known smooth muscle relaxant and a nitric oxide donor when intro...
The human population is regularly exposed to bisphenols. The first compound of this class, bisphenol...
Muscarine acetylcholine receptors were characterized in NB-OK1 cells using radioligand (H-3-NMS) bin...
Xanomeline is an agonist endowed with functional preference for M1/M4 muscarinic acetylcholine recep...
AbstractThe m2 and m3 muscarinic acetylcholine receptors were expressed in CHO cells and were shown ...