Insulin Neck : Is this the Earliest Sign of Insulin Resistance?

Acanthosis nigricans (AN) is so closely linked with insulin resistance (IR) that it has been called a clinical surrogate for laboratory-determined hyperinsulinemia. 1 AN presence can therefore indicate patients with IR, allowing implementation of interventions that may prevent progression to type 2 diabetes mellitus (DM). 2 We report 30 patients who presented with elevated body mass index (BMI) to correlate IR with different AN physical findings. Insulin neck (visibly increased texture on the posteriolateral neck) is the most sensitive physical finding for insulin resistance (IR). Insulin neck appears as visible lines, and/or furrows and ridges on the posterolateral neck. If neck texture is normal, IR is less likely to be present