Honokiol, a cell-permeable phenolic compound derived from the bark of magnolia trees, inhibits multiple autonomic responses. We determined the effects of honokiol on calcium signaling underlying transmission mediated by M3 muscarinic receptors expressed in Chinese hamster ovary (CHO) cells. Honokiol had a potent (EC50 ≈ 5 μM) inhibitory effect on store operated calcium entry (SOCE) that was induced by activation of the M3 receptors. This effect was specific, rapid and reversible, and was seen at concentrations not associated with cytotoxicity, inhibition of IP3 receptor-mediated calcium release, depletion of ER calcium stores, or disruption of M3 receptor binding. It is likely that an inhibition of SOCE contributes to honokiol disruption of...
1. Otilonium bromide (OB) is a smooth muscle relaxant used in the treatment of irritable bowel syndr...
Jing Sun,1 Xueqi Fu,1–3 Ye Liu,1 Yongsen Wang,1 Bo Huo,1 Yidi Guo,1 Xuefeng Gao,1 Wannan Li,1&...
Honokiol is a polyphenolic compound that exerts neuroprotective properties through a variety of mech...
Honokiol, a cell-permeable phenolic compound derived from the bark of magnolia trees, inhibits multi...
Background: Honokiol, a cell-permeable phenolic compound derived from the bark of magnolia trees and...
Cell-permeable biphenols, such as honokiol, present in herbal teas, inhibit autonomic responses. The...
Asian herbal medicine has used plants to treat many diseases for years. Two main compounds derived f...
BackgroundPerineural invasion (PNI) is an important pathologic feature of pancreatic cancer, and the...
1. The bark of the root and stem of various Magnolia species has been used in Traditional Chinese Me...
There is growing evidence that neuroinflammation is closely linked to depression. Honokiol, a biolog...
Honokiol (HNK) is a natural polyphenolic compound extracted from the bark and leaves of Magnolia gra...
[[abstract]]Background: Honokiol (HNK), a dimer of allylphenol obtained from the bark of Magnolia of...
<p>Calpain activity was measured with the fluorescent calpain substrate Suc-LLVY-AMC in N87, AGS, MK...
Plant-derived compounds with potent anti-inflammatory activity have attracted a great deal of attent...
The present study investigates the possible anti-nociceptive effect of intraperitoneal (i.p.) honoki...
1. Otilonium bromide (OB) is a smooth muscle relaxant used in the treatment of irritable bowel syndr...
Jing Sun,1 Xueqi Fu,1–3 Ye Liu,1 Yongsen Wang,1 Bo Huo,1 Yidi Guo,1 Xuefeng Gao,1 Wannan Li,1&...
Honokiol is a polyphenolic compound that exerts neuroprotective properties through a variety of mech...
Honokiol, a cell-permeable phenolic compound derived from the bark of magnolia trees, inhibits multi...
Background: Honokiol, a cell-permeable phenolic compound derived from the bark of magnolia trees and...
Cell-permeable biphenols, such as honokiol, present in herbal teas, inhibit autonomic responses. The...
Asian herbal medicine has used plants to treat many diseases for years. Two main compounds derived f...
BackgroundPerineural invasion (PNI) is an important pathologic feature of pancreatic cancer, and the...
1. The bark of the root and stem of various Magnolia species has been used in Traditional Chinese Me...
There is growing evidence that neuroinflammation is closely linked to depression. Honokiol, a biolog...
Honokiol (HNK) is a natural polyphenolic compound extracted from the bark and leaves of Magnolia gra...
[[abstract]]Background: Honokiol (HNK), a dimer of allylphenol obtained from the bark of Magnolia of...
<p>Calpain activity was measured with the fluorescent calpain substrate Suc-LLVY-AMC in N87, AGS, MK...
Plant-derived compounds with potent anti-inflammatory activity have attracted a great deal of attent...
The present study investigates the possible anti-nociceptive effect of intraperitoneal (i.p.) honoki...
1. Otilonium bromide (OB) is a smooth muscle relaxant used in the treatment of irritable bowel syndr...
Jing Sun,1 Xueqi Fu,1–3 Ye Liu,1 Yongsen Wang,1 Bo Huo,1 Yidi Guo,1 Xuefeng Gao,1 Wannan Li,1&...
Honokiol is a polyphenolic compound that exerts neuroprotective properties through a variety of mech...