Outcome after traumatic brain injury (TBI) is worsened by hemorrhagic shock (HS), but the optimal resuscitation approach is unclear. In particular, treatment of TBI patients with colloids remains controversial. We hypothesized that resuscitation with the colloids polynitroxylated albumin (PNA) or Hextend (HEX) is equal or superior to resuscitation with the crystalloids hypertonic (3%) saline (HTS) or lactated Ringer\u27s solution (LR) after TBI plus HS in mice. C57/BL6 mice (n = 30) underwent controlled cortical impact (CCI) and 90 min of volume-controlled HS (2 mL/100 g). The mice were randomized to resuscitation with LR, HEX, HTS, or PNA, followed by 30 min of test fluid administration targeting a mean arterial pressure (MAP) of \u3e50 mm...
Secondary insults such as hypotension or hemorrhagic shock (HS) can greatly worsen outcome after tra...
We have previously shown that early treatment with fresh frozen plasma (FFP) is neuroprotective in a...
Objectives: To evaluate the effectiveness of normal saline, hypertonic saline, and Ringer\u27s lacta...
Outcome after traumatic brain injury (TBI) is worsened by hemorrhagic shock (HS), but the optimal re...
Polynitroxylated-pegylated hemoglobin (PNPH), a bovine hemoglobin decorated with nitroxide and polye...
Traumatic brain injury (TBI) is often accompanied by hemorrhage, and treatment of hemorrhagic shock ...
BACKGROUND: Recently, studies have been conducted examining the efficacy of 3% hypertonic saline sol...
It was aimed to investigate the utility of different fluid replacement therapies in the acute phase ...
The original purpose of this study was to compare initial resuscitation of hemorrhagic hypotension a...
Background: Optimal fluid resuscitation strategy following combined traumatic brain injury (TBI) and...
Objective: Resuscitation of hemorrhagic hypotension after traumatic brain injury is challenging. A h...
Traumatic brain injury and hemorrhagic shock is associated with blood-brain barrier (BBB) breakdown ...
Background: Calcium is one of the triggers involved in ischemic neuronal death. Because hypotension ...
Aims: This study was performed to compare the effects of physiological saline and hypertonic saline ...
The resuscitation of polytrauma with hemorrhagic shock and traumatic brain injury (TBI) is a balance...
Secondary insults such as hypotension or hemorrhagic shock (HS) can greatly worsen outcome after tra...
We have previously shown that early treatment with fresh frozen plasma (FFP) is neuroprotective in a...
Objectives: To evaluate the effectiveness of normal saline, hypertonic saline, and Ringer\u27s lacta...
Outcome after traumatic brain injury (TBI) is worsened by hemorrhagic shock (HS), but the optimal re...
Polynitroxylated-pegylated hemoglobin (PNPH), a bovine hemoglobin decorated with nitroxide and polye...
Traumatic brain injury (TBI) is often accompanied by hemorrhage, and treatment of hemorrhagic shock ...
BACKGROUND: Recently, studies have been conducted examining the efficacy of 3% hypertonic saline sol...
It was aimed to investigate the utility of different fluid replacement therapies in the acute phase ...
The original purpose of this study was to compare initial resuscitation of hemorrhagic hypotension a...
Background: Optimal fluid resuscitation strategy following combined traumatic brain injury (TBI) and...
Objective: Resuscitation of hemorrhagic hypotension after traumatic brain injury is challenging. A h...
Traumatic brain injury and hemorrhagic shock is associated with blood-brain barrier (BBB) breakdown ...
Background: Calcium is one of the triggers involved in ischemic neuronal death. Because hypotension ...
Aims: This study was performed to compare the effects of physiological saline and hypertonic saline ...
The resuscitation of polytrauma with hemorrhagic shock and traumatic brain injury (TBI) is a balance...
Secondary insults such as hypotension or hemorrhagic shock (HS) can greatly worsen outcome after tra...
We have previously shown that early treatment with fresh frozen plasma (FFP) is neuroprotective in a...
Objectives: To evaluate the effectiveness of normal saline, hypertonic saline, and Ringer\u27s lacta...