Add to ORKGMarfan syndrome (MFS) is an autosomal dominant genetic disorder caused by mutations in the FBN1 gene. Although many peripheral tissues are affected, aortic complications, such as dilation, dissection and rupture, are the leading causes of MFS-related mortality. Aberrant TGF-beta signalling plays a major role in the pathophysiology of MFS. However, the contributing mechanisms are still poorly understood. Here, we aimed at identifying novel aorta-specific pathways involved in the pathophysiology of MFS. For this purpose, we employed the Fbn1 under-expressing mgR/mgR mouse model of MFS. We performed RNA-sequencing of aortic tissues of 9-week-old mgR/mgR mice compared with wild-type (WT) mice. With a false discovery rat
OBJECTIVE: Marfan syndrome (MFS) is caused by mutations in FBN1 (fibrillin-1), an extracellular matr...
[eng] Marfan Syndrome (MFS) is a rare, autosomal dominant disorder of the connective tissue that af...
ObjectiveMarfan syndrome is a systemic connective tissue disorder caused by mutations in the fibrill...
Marfan syndrome (MFS) is an autosomal dominant genetic disorder caused by mutations in the FBN1 gene...
Marfan syndrome (MFS) is an autosomal dominant genetic disorder caused by mutations in the FBN1 gene...
ObjectiveFibrillin-1 hypomorphic mice (mgR/mgR) are accepted as a model of Marfan syndrome. Phenotyp...
Marfan Syndrome (MFS) is a highly penetrant, autosomal dominant disease of the connective tissues ca...
Marfan syndrome (MFS) is one of several related disorders that is driven by increased TGFβ signaling...
Marfan syndrome (MFS) is a connective tissue disorder caused by mutations in fibrillin-1, a matrix c...
Marfan syndrome (MFS) represents a genetic disorder with variable phenotypic expression. The main ca...
Thoracic aortic aneurysm is a potentially life-threatening disease with a strong genetic contributio...
Background: Enhanced TGFβ signaling is observed in several heritable forms of thoracic aortic aneury...
The starting point, in Marfan syndrome (MFS) appears to be the mutation of fi brillin-1 gene whose d...
Marfan syndrome (MFS) is a heritable connective tissue disorder caused by mutations in FBN1, which e...
The molecular and cellular processes leading to aortic aneurysm development in Marfan syndrome (MFS)...
OBJECTIVE: Marfan syndrome (MFS) is caused by mutations in FBN1 (fibrillin-1), an extracellular matr...
[eng] Marfan Syndrome (MFS) is a rare, autosomal dominant disorder of the connective tissue that af...
ObjectiveMarfan syndrome is a systemic connective tissue disorder caused by mutations in the fibrill...
Marfan syndrome (MFS) is an autosomal dominant genetic disorder caused by mutations in the FBN1 gene...
Marfan syndrome (MFS) is an autosomal dominant genetic disorder caused by mutations in the FBN1 gene...
ObjectiveFibrillin-1 hypomorphic mice (mgR/mgR) are accepted as a model of Marfan syndrome. Phenotyp...
Marfan Syndrome (MFS) is a highly penetrant, autosomal dominant disease of the connective tissues ca...
Marfan syndrome (MFS) is one of several related disorders that is driven by increased TGFβ signaling...
Marfan syndrome (MFS) is a connective tissue disorder caused by mutations in fibrillin-1, a matrix c...
Marfan syndrome (MFS) represents a genetic disorder with variable phenotypic expression. The main ca...
Thoracic aortic aneurysm is a potentially life-threatening disease with a strong genetic contributio...
Background: Enhanced TGFβ signaling is observed in several heritable forms of thoracic aortic aneury...
The starting point, in Marfan syndrome (MFS) appears to be the mutation of fi brillin-1 gene whose d...
Marfan syndrome (MFS) is a heritable connective tissue disorder caused by mutations in FBN1, which e...
The molecular and cellular processes leading to aortic aneurysm development in Marfan syndrome (MFS)...
OBJECTIVE: Marfan syndrome (MFS) is caused by mutations in FBN1 (fibrillin-1), an extracellular matr...
[eng] Marfan Syndrome (MFS) is a rare, autosomal dominant disorder of the connective tissue that af...
ObjectiveMarfan syndrome is a systemic connective tissue disorder caused by mutations in the fibrill...