Albumin is a large, highly abundant protein circulating in the blood stream which is regulated and actively recycled via the neonatal Fc receptor (FcRn). In humans this results in serum albumin having an exceptional long half-life of ~21 days. Some time ago it was realized that these intrinsic properties could be harnessed and albumin could be used as a privileged drug delivery vehicle. However, active development of albumin based therapeutics has been hampered by the lack of economic, relevant experimental models which can accurately recapitulate human albumin metabolism and pharmacokinetics. In mice for example, introduced human albumin is not recycled and is catabolized rapidly. This is mainly due to the failure of mouse FcRn to bind hum...
A key element for the successful development of novel therapeutic antibodies is to fully understand ...
Albumin has a serum half-life of 3 weeks in humans. This feature can be used to improve the pharmaco...
Serum albumin shows slow clearance from circulation due to neonatal Fc receptor (FcRn)-mediated recy...
Albumin is a large, highly abundant protein circulating in the blood stream which is regulated and a...
Serum albumin is the major determinant of blood colloidal osmotic pressure acting as a depot and dis...
Albumin has a long serum half-life due to its unique ability to bind the cellular neonatal Fc recept...
Albumin has a serum half-life of 3 weeks in humans. This has been utilized to extend the serum persi...
A major challenge for the therapeutic use of many peptides and proteins is their short circulatory h...
Needle-free uptake across mucosal barriers is a preferred route for delivery of biologics, but the e...
Needle-free uptake across mucosal barriers is a preferred route for delivery of biologics, but the e...
An increasing number of protein drugs are used in the clinic to treat a broad range of diseases. How...
Serum albumin shows slow clearance from circulation due to neonatal Fc receptor (FcRn)-mediated recy...
The neonatal Fc receptor (FcRn) regulates the serum half-life of both IgG and albumin through a pH-d...
Mice genetically engineered to express human FcRn are valuable models for the evaluation of therapeu...
Albumin is the most abundant protein in blood and plays a pivotal role as a multitransporter of a wi...
A key element for the successful development of novel therapeutic antibodies is to fully understand ...
Albumin has a serum half-life of 3 weeks in humans. This feature can be used to improve the pharmaco...
Serum albumin shows slow clearance from circulation due to neonatal Fc receptor (FcRn)-mediated recy...
Albumin is a large, highly abundant protein circulating in the blood stream which is regulated and a...
Serum albumin is the major determinant of blood colloidal osmotic pressure acting as a depot and dis...
Albumin has a long serum half-life due to its unique ability to bind the cellular neonatal Fc recept...
Albumin has a serum half-life of 3 weeks in humans. This has been utilized to extend the serum persi...
A major challenge for the therapeutic use of many peptides and proteins is their short circulatory h...
Needle-free uptake across mucosal barriers is a preferred route for delivery of biologics, but the e...
Needle-free uptake across mucosal barriers is a preferred route for delivery of biologics, but the e...
An increasing number of protein drugs are used in the clinic to treat a broad range of diseases. How...
Serum albumin shows slow clearance from circulation due to neonatal Fc receptor (FcRn)-mediated recy...
The neonatal Fc receptor (FcRn) regulates the serum half-life of both IgG and albumin through a pH-d...
Mice genetically engineered to express human FcRn are valuable models for the evaluation of therapeu...
Albumin is the most abundant protein in blood and plays a pivotal role as a multitransporter of a wi...
A key element for the successful development of novel therapeutic antibodies is to fully understand ...
Albumin has a serum half-life of 3 weeks in humans. This feature can be used to improve the pharmaco...
Serum albumin shows slow clearance from circulation due to neonatal Fc receptor (FcRn)-mediated recy...