The transcription factor Ebf1 is an important determinant of early B lymphopoiesis. To gain insight into the functions of Ebf1 at distinct stages of differentiation, we conditionally inactivated Ebf1. We found that Ebf1 is required for the proliferation, survival, and signaling of pro-B cells and peripheral B-cell subsets, including B1 cells and marginal zone B cells. The proliferation defect of Ebf1-deficient pro-B cells and the impaired expression of multiple cell cycle regulators are overcome by transformation with v-Abl. The survival defect of transformed Ebf1(fl/fl) pro-B cells can be rescued by the forced expression of the Ebf1 targets c-Myb or Bcl-x(L). In mature B cells, Ebf1 deficiency interferes with signaling via the B-cell-activ...
The transcription factors EBF1 and Pax5 have been linked to activation of the B cell lineage program...
Ebf1 is a transcription factor with documented dose dependent functions in normal and malignant B-ly...
During the last decades, many studies have investigated the transcriptional and epigenetic regulatio...
The transcription factor Ebf1 is an important determinant of early B lymphopoiesis. To gain insight ...
SummaryThe transcription factor early B cell factor-1 (Ebf1) is a key determinant of B lineage speci...
B lymphocyte differentiation is dependent on an intricate interplay of transcription factors and sig...
B lymphocyte differentiation is dependent on an intricate interplay of transcription factors and sig...
The transcription factor early B cell factor-1 (Ebf1) is a key determinant of B lineage specificatio...
Transcription factor EBF1 (early B-cell factor 1) regulates early B-cell differentiation by poising ...
Alternative lineage restriction and B cell fate commitment require the transcription factor Pax5, bu...
B-cell fate determination requires the action of transcription factors that operate in a regulatory ...
B cell development proceeds through a defined set of cellular intermediates that give rise to mature...
AbstractThe transcription factors EBF and E2A are required at a similar step in early B cell differe...
B-cell fate determination requires the action of transcription factors that operate in a regulatory ...
EBF1 is a highly conserved transcription factor that plays pivotal roles in the development of norma...
The transcription factors EBF1 and Pax5 have been linked to activation of the B cell lineage program...
Ebf1 is a transcription factor with documented dose dependent functions in normal and malignant B-ly...
During the last decades, many studies have investigated the transcriptional and epigenetic regulatio...
The transcription factor Ebf1 is an important determinant of early B lymphopoiesis. To gain insight ...
SummaryThe transcription factor early B cell factor-1 (Ebf1) is a key determinant of B lineage speci...
B lymphocyte differentiation is dependent on an intricate interplay of transcription factors and sig...
B lymphocyte differentiation is dependent on an intricate interplay of transcription factors and sig...
The transcription factor early B cell factor-1 (Ebf1) is a key determinant of B lineage specificatio...
Transcription factor EBF1 (early B-cell factor 1) regulates early B-cell differentiation by poising ...
Alternative lineage restriction and B cell fate commitment require the transcription factor Pax5, bu...
B-cell fate determination requires the action of transcription factors that operate in a regulatory ...
B cell development proceeds through a defined set of cellular intermediates that give rise to mature...
AbstractThe transcription factors EBF and E2A are required at a similar step in early B cell differe...
B-cell fate determination requires the action of transcription factors that operate in a regulatory ...
EBF1 is a highly conserved transcription factor that plays pivotal roles in the development of norma...
The transcription factors EBF1 and Pax5 have been linked to activation of the B cell lineage program...
Ebf1 is a transcription factor with documented dose dependent functions in normal and malignant B-ly...
During the last decades, many studies have investigated the transcriptional and epigenetic regulatio...