In eutherian mammals, implantation and establishment of the chorioallantoic placenta are essential for embryo development and survival. As a maternal response to implantation, uterine stromal cells proliferate, differentiate, and generate the decidua, which encapsulates the conceptus and forms the maternal part of the placenta. Little is known about decidual functions and the molecular interactions that regulate its development and maintenance. Here we show that the receptor for the cytokine interleukin-11 (IL-11Ralpha) is required specifically for normal establishment of the decidua. Females homozygous for a hypomorphic IL-11Ralpha allele are fertile and their blastocysts implant and elicit the decidual response. Because of reduce...
BACKGROUND: Human trophoblast invasion and differentiation are essential for a successful pregnancy ...
<div><p>Decidualization renders the endometrium transiently receptive to an implanting blastocyst al...
Decidualization is a crucial step for human reproduction, which is a prerequisite for embryo implant...
Interleukin-11 (IL-11) is a multifunctional hematopoietic growth factor that has been implicated in ...
Embryo implantation, endometrial stromal cell decidualization and formation of a functional placenta...
Embryo implantation and subsequent decidualization, trophoblast invasion and formation of a function...
Preeclampsia is associated with increased systemic inflammation and superficial trophoblast invasion...
Preeclampsia is associated with increased systemic inflammation and superficial trophoblast invasion...
Decidua is a transient uterine tissue shared by mammals with hemochorial placenta and is essential f...
There are many similarities between trophoblast and cancer cells. Both share similar capabilities si...
1 Short title: IL11 inhibits human EVT invasion Interleukin 11 inhibits human trophoblast invasion, ...
Leukemia inhibitory factor (LIF) and Interleukin (IL) 11, two cytokines of the IL-6 Family, have bee...
Preeclampsia is an insidious disease, unique to humans, affecting ∼8% of pregnancies. There are no e...
Placental morphogenesis and nutrient transfer function are regulated by growth factors at the foeto-...
Implantation, a critical step for establishing pregnancy, requires molecular and cellular events res...
BACKGROUND: Human trophoblast invasion and differentiation are essential for a successful pregnancy ...
<div><p>Decidualization renders the endometrium transiently receptive to an implanting blastocyst al...
Decidualization is a crucial step for human reproduction, which is a prerequisite for embryo implant...
Interleukin-11 (IL-11) is a multifunctional hematopoietic growth factor that has been implicated in ...
Embryo implantation, endometrial stromal cell decidualization and formation of a functional placenta...
Embryo implantation and subsequent decidualization, trophoblast invasion and formation of a function...
Preeclampsia is associated with increased systemic inflammation and superficial trophoblast invasion...
Preeclampsia is associated with increased systemic inflammation and superficial trophoblast invasion...
Decidua is a transient uterine tissue shared by mammals with hemochorial placenta and is essential f...
There are many similarities between trophoblast and cancer cells. Both share similar capabilities si...
1 Short title: IL11 inhibits human EVT invasion Interleukin 11 inhibits human trophoblast invasion, ...
Leukemia inhibitory factor (LIF) and Interleukin (IL) 11, two cytokines of the IL-6 Family, have bee...
Preeclampsia is an insidious disease, unique to humans, affecting ∼8% of pregnancies. There are no e...
Placental morphogenesis and nutrient transfer function are regulated by growth factors at the foeto-...
Implantation, a critical step for establishing pregnancy, requires molecular and cellular events res...
BACKGROUND: Human trophoblast invasion and differentiation are essential for a successful pregnancy ...
<div><p>Decidualization renders the endometrium transiently receptive to an implanting blastocyst al...
Decidualization is a crucial step for human reproduction, which is a prerequisite for embryo implant...