Add to ORKGBACKGROUND: The development of long-term allograft survival and understanding the mechanism(s) by which it is induced are major goals of experimental transplantation. Studies by several different investigators have provided conflicting evidence for the role of interleukin (IL)-4 in the process of allograft rejection or long-term allograft survival. These studies examine the role of IL-4 in experimental cardiac allograft rejection and in inducing long-term allograft survival. A possible mechanism for long-term allograft maintenance via alternative allosensitization is discussed. METHODS: Adult IL-4-intact or IL-4-deficient (knockout, KO) C57BL/6 (B6) mice were transplanted with heterotopic DBA/2 cardiac allografts and immunosuppress...
Alloantibodies can play a key role in acute and chronic allograft rejection. However, relatively lit...
Neonatal injection of semiallogeneic cells is known to promote differentiation of donor-specific CD4...
Little is known about heart tissue/donor dendritic cells, which play a key role in mounting alloimmu...
BACKGROUND: This study addresses the question of the mechanism for maintaining tolerance to donor al...
INTRODUCTION: CTLA-4 is a negative regulatory molecule upregulated on activated T cells; however, it...
IL-4 is thought to promote induction of transplantation tolerance and alloantigen-specific CD4⁺CD25⁺...
A major goal in clinical organ transplantation is to devise new strategies for the induction of spec...
<p>A) & B) Frozen sections of tolerated cardiac allografts were stained for CD4 on day 40 post-trans...
Summary: MHC alloantigen is recognized by two pathways: “directly,” intact on donor cells, or “indir...
BACKGROUND: We examined whether oral administration of alloantigen could induce the prolonged surviv...
Background. Previous studies have demonstrated that anti-CD40L or anti-B7 requires the presence of C...
‡These authors contributed equally to this work. Chronic cardiac allograft rejection is the major ba...
The long-term success of transplantation is limited by the need for immunosuppression; thus, toleran...
The long-term success of transplantation is limited by the need for immunosuppression; thus, toleran...
In all but a small minority of cases, continued survival of solid organ grafts after transplantation...
Alloantibodies can play a key role in acute and chronic allograft rejection. However, relatively lit...
Neonatal injection of semiallogeneic cells is known to promote differentiation of donor-specific CD4...
Little is known about heart tissue/donor dendritic cells, which play a key role in mounting alloimmu...
BACKGROUND: This study addresses the question of the mechanism for maintaining tolerance to donor al...
INTRODUCTION: CTLA-4 is a negative regulatory molecule upregulated on activated T cells; however, it...
IL-4 is thought to promote induction of transplantation tolerance and alloantigen-specific CD4⁺CD25⁺...
A major goal in clinical organ transplantation is to devise new strategies for the induction of spec...
<p>A) & B) Frozen sections of tolerated cardiac allografts were stained for CD4 on day 40 post-trans...
Summary: MHC alloantigen is recognized by two pathways: “directly,” intact on donor cells, or “indir...
BACKGROUND: We examined whether oral administration of alloantigen could induce the prolonged surviv...
Background. Previous studies have demonstrated that anti-CD40L or anti-B7 requires the presence of C...
‡These authors contributed equally to this work. Chronic cardiac allograft rejection is the major ba...
The long-term success of transplantation is limited by the need for immunosuppression; thus, toleran...
The long-term success of transplantation is limited by the need for immunosuppression; thus, toleran...
In all but a small minority of cases, continued survival of solid organ grafts after transplantation...
Alloantibodies can play a key role in acute and chronic allograft rejection. However, relatively lit...
Neonatal injection of semiallogeneic cells is known to promote differentiation of donor-specific CD4...
Little is known about heart tissue/donor dendritic cells, which play a key role in mounting alloimmu...