C3H/HeJBir mice are a new substrain that spontaneously develop colitis early in life. This study was done to determine the T cell reactivity of C3H/HeJBir mice to candidate antigens that might be involved in their disease. C3H/HeJBir CD4+ T cells were strongly reactive to antigens of the enteric bacterial flora, but not to epithelial or food antigens. The stimulatory material in the enteric bacteria was trypsin sensitive and restricted by class II major histocompatibility complex molecules, but did not have the properties of a superantigen. The precursor frequency of interleuken (IL)-2-producing, bacterial-reactive CD4+ T cells in colitic mice was 1 out of 2,000 compared to 1 out of 20,000-25,000 in noncolitic control mice. These T...
Inflammatory bowel disease (IBD) is thought to result from either an abnormal immunological response...
Current therapies to treat inflammatory bowel diseases have limited efficacy, significant side effec...
A helper T cell type 1-mediated colitis driven by enteric bacteria develops in severe combined immun...
The idiopathic inflammatory bowel diseases, ulcerative colitis and Crohn\u27s disease, are chronic d...
C3H/HeJBir is a substrain of C3H/HeJ mice that was generated by selective breeding for the phenotype...
Although the etiology of human inflammatory bowel disease (IBD) has not yet been completely defined,...
Although the etiology of human inflammatory bowel disease (IBD) has not yet been completely defined,...
Inflammatory bowel disease (IBD) comprising Crohn s disease and ulcerative colitis is a disease that...
Mice rendered deficient in the production of interleukin 10 (IL-10-/-) develop a chronic inflammator...
CD4(+) regulatory T cells have been shown to prevent intestinal inflammation; however, it is not kno...
Inflammatory bowel disease (IBD) is a chronic inflammation which affects the gastrointestinal tract ...
Murine models of inflammatory bowel disease (IBD) are useful tools for the study of the pathogenesis...
Although the etiology of inflammatory bowel disease (IBD) remains unknown, a major working hypothesi...
It is now well established that the intestinal flora plays an important role in the pathogenesis of ...
Murine models of inflammatory bowel disease (IBD) are useful tools for the study of the pathogenesis...
Inflammatory bowel disease (IBD) is thought to result from either an abnormal immunological response...
Current therapies to treat inflammatory bowel diseases have limited efficacy, significant side effec...
A helper T cell type 1-mediated colitis driven by enteric bacteria develops in severe combined immun...
The idiopathic inflammatory bowel diseases, ulcerative colitis and Crohn\u27s disease, are chronic d...
C3H/HeJBir is a substrain of C3H/HeJ mice that was generated by selective breeding for the phenotype...
Although the etiology of human inflammatory bowel disease (IBD) has not yet been completely defined,...
Although the etiology of human inflammatory bowel disease (IBD) has not yet been completely defined,...
Inflammatory bowel disease (IBD) comprising Crohn s disease and ulcerative colitis is a disease that...
Mice rendered deficient in the production of interleukin 10 (IL-10-/-) develop a chronic inflammator...
CD4(+) regulatory T cells have been shown to prevent intestinal inflammation; however, it is not kno...
Inflammatory bowel disease (IBD) is a chronic inflammation which affects the gastrointestinal tract ...
Murine models of inflammatory bowel disease (IBD) are useful tools for the study of the pathogenesis...
Although the etiology of inflammatory bowel disease (IBD) remains unknown, a major working hypothesi...
It is now well established that the intestinal flora plays an important role in the pathogenesis of ...
Murine models of inflammatory bowel disease (IBD) are useful tools for the study of the pathogenesis...
Inflammatory bowel disease (IBD) is thought to result from either an abnormal immunological response...
Current therapies to treat inflammatory bowel diseases have limited efficacy, significant side effec...
A helper T cell type 1-mediated colitis driven by enteric bacteria develops in severe combined immun...