Add to ORKGDespite the influence of obesity in predisposing to many diseases, and evidence for high heritability, efforts to identify human genes with major effects on bodyweight have not yet been successful. In contrast, remarkable progress has been made in the identification and characterization of the genes mutated in five monogenic mouse models of obesity. These genes have led to new insights into the etiology of obesity and provide promising targets for therapeutic intervention
Obesity has reached epidemic proportions and is recognised as a significant global health problem. I...
AbstractTransgenic mice have been produced that either lack or overproduce neuroregulatory substance...
It has long been known that there is a genetic component to obesity, and that characterizing this un...
Obesity is a major public health concern. This condition results from a constant and complex interpl...
Obesity, as defined by any number of metrics, aggregates in families but does not segregate as a sim...
Obesity is an important cause of morbidity and mortality in developed countries, and is also becomin...
929-936Obesity, a global problem, is a multifactorial disorder. The factors are environmental, metab...
The prevalence of obesity has tripled over the past four decades, imposing an enormous burden on peo...
It has been found that there is a genetic components behind obesity. Genome wide associated studies ...
Obesity is the outcome of an extreme difference between the energy intake and the energy expended, w...
The heritability of obesity and body weight in general is high. A small number of confirmed monogeni...
Rare genetic obesity disorders are characterized by mutations of genes strongly involved in the cent...
Motivation: Genome-wide experiments only rarely show resounding success in yielding genes associated...
Obesity and its comorbidities are taking an increasing toll on human health. Key pathways that were ...
Obesity, a phenotype having high heritability in humans, constitutes the major risk factor predispos...
Obesity has reached epidemic proportions and is recognised as a significant global health problem. I...
AbstractTransgenic mice have been produced that either lack or overproduce neuroregulatory substance...
It has long been known that there is a genetic component to obesity, and that characterizing this un...
Obesity is a major public health concern. This condition results from a constant and complex interpl...
Obesity, as defined by any number of metrics, aggregates in families but does not segregate as a sim...
Obesity is an important cause of morbidity and mortality in developed countries, and is also becomin...
929-936Obesity, a global problem, is a multifactorial disorder. The factors are environmental, metab...
The prevalence of obesity has tripled over the past four decades, imposing an enormous burden on peo...
It has been found that there is a genetic components behind obesity. Genome wide associated studies ...
Obesity is the outcome of an extreme difference between the energy intake and the energy expended, w...
The heritability of obesity and body weight in general is high. A small number of confirmed monogeni...
Rare genetic obesity disorders are characterized by mutations of genes strongly involved in the cent...
Motivation: Genome-wide experiments only rarely show resounding success in yielding genes associated...
Obesity and its comorbidities are taking an increasing toll on human health. Key pathways that were ...
Obesity, a phenotype having high heritability in humans, constitutes the major risk factor predispos...
Obesity has reached epidemic proportions and is recognised as a significant global health problem. I...
AbstractTransgenic mice have been produced that either lack or overproduce neuroregulatory substance...
It has long been known that there is a genetic component to obesity, and that characterizing this un...