Add to ORKGPhysiological and behavioral measurements were made in a cohort of 29-month-old male C57BL/6J mice to determine whether any correlated significantly with lifespan. Significant linear relationships with lifespan were found among the physiological measures, including hematocrit and hemoglobin levels and collagen denaturation rate; however, body weight failed to be a significant predictor of survival. Among the behavioral variables studied, significant quadratic relationships with lifespan were found for exploratory activity and passive avoidance learning, while performance on a rotorod and a tightwire showed no significant relationships with lifespan. Through the use of multiple regression techniques, about one-third of the variance ...
Aging is associated with distinct phenotypical, physiological, and functional changes, leading to di...
Abstract Aim Aging is thought to coincide with gradual and progressive changes in brain function and...
Longitudinal approaches for disease-monitoring in old animals face survival and frailty limitations,...
Aging is characterized generally by progressive and overall physiological decline of functions and i...
Laboratory mice are predominantly used for one experiment only, i.e., new mice are ordered or bred f...
Tests of physiological changes with age are illustrated by collagen denaturation times of tail tendo...
The relationship between chronological age (lifespan) and biological age (healthspan) varies amongst...
New evidence refers to a high degree of heterogeneity in normal but also Alzheimer’s disease (AD) cl...
International audienceAging is the major risk factor for the development of chronic diseases. After ...
There have been some observations that low body weight and a low level of some hormones (e.g. IGF-1)...
<p>A, C. When lifespan of WT mice was plotted against their maximal body weight, a correlation was f...
Current concepts regarding the biology of aging are primarily based on studies aimed at identifying ...
Current concepts regarding the biology of aging are primarily based on studies aimed at identifying ...
The identification of predictive markers of life span would help to unravel the underlying mechanism...
Voluntary locomotor activity may be affected by a variety of intrinsic factors (e.g., physiology) an...
Aging is associated with distinct phenotypical, physiological, and functional changes, leading to di...
Abstract Aim Aging is thought to coincide with gradual and progressive changes in brain function and...
Longitudinal approaches for disease-monitoring in old animals face survival and frailty limitations,...
Aging is characterized generally by progressive and overall physiological decline of functions and i...
Laboratory mice are predominantly used for one experiment only, i.e., new mice are ordered or bred f...
Tests of physiological changes with age are illustrated by collagen denaturation times of tail tendo...
The relationship between chronological age (lifespan) and biological age (healthspan) varies amongst...
New evidence refers to a high degree of heterogeneity in normal but also Alzheimer’s disease (AD) cl...
International audienceAging is the major risk factor for the development of chronic diseases. After ...
There have been some observations that low body weight and a low level of some hormones (e.g. IGF-1)...
<p>A, C. When lifespan of WT mice was plotted against their maximal body weight, a correlation was f...
Current concepts regarding the biology of aging are primarily based on studies aimed at identifying ...
Current concepts regarding the biology of aging are primarily based on studies aimed at identifying ...
The identification of predictive markers of life span would help to unravel the underlying mechanism...
Voluntary locomotor activity may be affected by a variety of intrinsic factors (e.g., physiology) an...
Aging is associated with distinct phenotypical, physiological, and functional changes, leading to di...
Abstract Aim Aging is thought to coincide with gradual and progressive changes in brain function and...
Longitudinal approaches for disease-monitoring in old animals face survival and frailty limitations,...