Add to ORKGThe study of genetic variation in mice offers a powerful experimental platform for understanding gene function. Complex trait analysis, gene-targeting and gene-trapping technologies, as well as insertional and chemical mutagenesis approaches are becoming increasingly sophisticated and provide a variety of options for cataloguing gene activities and interactions. In this review we discuss fundamental and practical concepts related to chemical mutagenesis and we highlight the growing list of strategies for performing mutagenesis screens in mice. Gene-driven and diverse types of phenotype-driven screens provide several options for the recovery of the invaluable variety of alleles generated by chemical mutagenesis. The unique advantage...
Mutagenesis screens in the mouse have been proven useful for the identification of novel gene functi...
This paper is aimed principally at bioinformaticians and biologists as an introduction to recent adv...
In this chapter we give an overview of mutagenesis methods in the mouse as they evolved over the las...
With the completion of the mouse and human genome sequences, a major challenge is the functional cha...
As the human genome project approaches completion, the challenge for mammalian geneticists is to dev...
peer reviewedA major challenge in post-genomics is the systematic determination of mammalian gene fu...
Abstract. A valuable approach to investigating a bloiogical process is to study the effect of mutati...
After sequencing the human and mouse genomes, the annotation of these sequences with biological func...
Recent advances in high-throughput gene targeting and conditional mutagenesis are creating new and p...
When compared to other model organisms whose genome is sequenced, the number of mutations identified...
Mutagenesis of mice with N-ethyl-N-nitrosourea (ENU) is a phenotype-driven approach to unravel gene ...
The chemical mutagenesis of mouse embryonic stem (ES) cells is an approach complementary to chemical...
Random insertional mutagenesis can reveal a lot of insight in specific gene function and phenotypica...
One of the long-term goals of mutagenesis programs in the mouse has been to generate mutant lines to...
Phenotype-driven mutagenesis approaches in the mouse will deliver a vastly expanded mouse mutant res...
Mutagenesis screens in the mouse have been proven useful for the identification of novel gene functi...
This paper is aimed principally at bioinformaticians and biologists as an introduction to recent adv...
In this chapter we give an overview of mutagenesis methods in the mouse as they evolved over the las...
With the completion of the mouse and human genome sequences, a major challenge is the functional cha...
As the human genome project approaches completion, the challenge for mammalian geneticists is to dev...
peer reviewedA major challenge in post-genomics is the systematic determination of mammalian gene fu...
Abstract. A valuable approach to investigating a bloiogical process is to study the effect of mutati...
After sequencing the human and mouse genomes, the annotation of these sequences with biological func...
Recent advances in high-throughput gene targeting and conditional mutagenesis are creating new and p...
When compared to other model organisms whose genome is sequenced, the number of mutations identified...
Mutagenesis of mice with N-ethyl-N-nitrosourea (ENU) is a phenotype-driven approach to unravel gene ...
The chemical mutagenesis of mouse embryonic stem (ES) cells is an approach complementary to chemical...
Random insertional mutagenesis can reveal a lot of insight in specific gene function and phenotypica...
One of the long-term goals of mutagenesis programs in the mouse has been to generate mutant lines to...
Phenotype-driven mutagenesis approaches in the mouse will deliver a vastly expanded mouse mutant res...
Mutagenesis screens in the mouse have been proven useful for the identification of novel gene functi...
This paper is aimed principally at bioinformaticians and biologists as an introduction to recent adv...
In this chapter we give an overview of mutagenesis methods in the mouse as they evolved over the las...