強心配糖体のコリンエステラーゼ活性に及ぼす影響 第1報 強心配糖体と猫の非特異的コリンエステラーゼ

A definite dose of digitoxin, g-strophanthin or convallatoxin was injected every five minutes into vein of cat till heart standstill occurred. Cholinesterase activity was determined by manometric techniques on serial samples of cat serum obtained every ten minutes. Digitoxin produced an acceleration of cholinesterase activity in small doses and an inhibition in large doses. G-strophanthin and convallatoxin accelerated the cholinesterase activity parallel with the increase of doses administered, without producing an inhibition of cholinesterase until heart standstill occurred. It is, therefore, concluded that digitoxin exerts a differnt effect on serum cholinesterase as compared to g-strophanthin or convallatoxin. But, it is unknown whether the effect of cardiac glycosides on nonspecific serum cholinesterase is related with the heart action or not.departmental bulletin pape