Minor cellular lipids such as diacylglycerol, phosphatidic acid and lysophosphatidic acid are now established to act as lipid mediators regulating a wide range of cellular functions. To maintain orchestrated cellular functions, the concentration of such lipids needs to be strictly regulated by the balance of production and attenuation achieved by the action of metabolic enzymes. We are the first to report successful molecular cloning of two classes of enzymes, i. e. diacylglycerol kinase (DGK) and phosphatidic acid phosphatase (PAP). DGK has been disclosed to be involved in the attenuation of diacylglycerol-signal occurring within spatio-temporally regulated signaling complexes. PAP, on the other hand, acts as an ecto-enzyme degrading extra...
AbstractDiacylglycerol kinases (DGKs) regulate the key signaling intermediates diacylglycerol (DAG) ...
It is well established that the nucleus is endowed with enzymes that are involved in lipid-dependent...
Phosphoinositide metabolism is intimately involved in cellular signal transduction. In response to e...
Minor cellular lipids such as diacylglycerol, phosphatidic acid and lysophosphatidic acid are now es...
Minor cellular lipids such as diacylglycerol, phosphatidic acid and lysophosphatidic acid are now es...
Diacylglycerol kinases (DGKs) phosphorylate diacylglycerol (DG), catalyzing its conversion into phos...
dissertationDiacylglycerol kinase (DGK) phosphorylates diacylglycerol (DAG) to form phosphatidic aci...
Diacylglycerol kinase (DGK, EC 2.7.1.107) is a lipid kinase that phosphorylates diacylglycerol (DAG)...
Phosphatidic acid (PA) is a glycerophospholipid intermediate in the triglyceride synthesis pathway t...
Diacylglycerol is a key regulator of cell physiology, controlling the membrane recruitment and activ...
The existence of intranuclear lipid-dependent signal transduction systems has been demonstrated by s...
Diacylglycerol kinases (DGKs) are a diverse family of enzymes that catalyze the conversion of diacyl...
Although originally restricted to their structural role as major constituents of membranes, lipids a...
Diacylglycerol kinases are key modulators of levels of diacylglycerol, a second messenger involved i...
The existence of intranuclear lipid-dependent signal transduction systems has been demonstrated by s...
AbstractDiacylglycerol kinases (DGKs) regulate the key signaling intermediates diacylglycerol (DAG) ...
It is well established that the nucleus is endowed with enzymes that are involved in lipid-dependent...
Phosphoinositide metabolism is intimately involved in cellular signal transduction. In response to e...
Minor cellular lipids such as diacylglycerol, phosphatidic acid and lysophosphatidic acid are now es...
Minor cellular lipids such as diacylglycerol, phosphatidic acid and lysophosphatidic acid are now es...
Diacylglycerol kinases (DGKs) phosphorylate diacylglycerol (DG), catalyzing its conversion into phos...
dissertationDiacylglycerol kinase (DGK) phosphorylates diacylglycerol (DAG) to form phosphatidic aci...
Diacylglycerol kinase (DGK, EC 2.7.1.107) is a lipid kinase that phosphorylates diacylglycerol (DAG)...
Phosphatidic acid (PA) is a glycerophospholipid intermediate in the triglyceride synthesis pathway t...
Diacylglycerol is a key regulator of cell physiology, controlling the membrane recruitment and activ...
The existence of intranuclear lipid-dependent signal transduction systems has been demonstrated by s...
Diacylglycerol kinases (DGKs) are a diverse family of enzymes that catalyze the conversion of diacyl...
Although originally restricted to their structural role as major constituents of membranes, lipids a...
Diacylglycerol kinases are key modulators of levels of diacylglycerol, a second messenger involved i...
The existence of intranuclear lipid-dependent signal transduction systems has been demonstrated by s...
AbstractDiacylglycerol kinases (DGKs) regulate the key signaling intermediates diacylglycerol (DAG) ...
It is well established that the nucleus is endowed with enzymes that are involved in lipid-dependent...
Phosphoinositide metabolism is intimately involved in cellular signal transduction. In response to e...