Biosynthetic Pattern of Liver Glycogen in Malignancy and Under Therapeutic Stress

The hypoglycemic effect exerted by the tumor tissue causes an increased consumption of blood glucose from the surrounding medium and this in turn results in an elevated mobilization of host's liver glycogen. In the present paper [T-?H] glucose has been injected in normal mice and those bearing S 180, and others treated with the chemotherapeutic agents 5-fluoro uracil and 5-fluoro deoxy uridine causing tumor regression. Information has been furnished in the present paper regarding the utilization pattern of the tritiated glucose in the liver glycogen along with the isotope clearance from the blood in normalcy, malignancy and under therapeutic stress. The check of the neoplastic process due to the therapeutic effectiveness of drugs exhibits parallelism with respect to the significant revival of liver glycogen and the blood glucose level in the treated groups. This is also reflected in the significant increase of incorporation of radioactive precursor in liver glycogen concomitant with decrease in the rate of utilization of isotope from the blood level in the treated series.departmental bulletin pape