Add to ORKGA DNA mapping panel derived from an interspecific backcross was used to position the mouse insulin-2 locus (Ins-2) on Chromosome 7, near H19 (0/114 recombinants) and Th (1/114 recombinants). Ins-2 is part of a human-mouse conserved linkage group that includes Th, H19, and Igf-2. Analysis of segregation in the F2 generation from the cross C57BL/6J-tub/tub x CAST/Ei demonstrated that Ins-2 and the obesity mutant tubby (tub) are distinct loci, thus eliminating Ins-2 as a candidate gene for tub. These results also refine the estimated genetic distance between tub and Hbb to 2.4 +/- 1.4 cM. The predicted location for a human homolog of tubby is HSA 11p15
Tubby, an autosomal recessive mutation, mapping to mouse chromosome 7, was recently found to be the ...
The tubby gene family consists of four members, TUB, TULP1, TULP2 and TULP3, with unknown function. ...
<p>The top two QTLs are chromosome 2 (LOD = 6.5) and chromosome 19 (LOD = 5.4). We select these two ...
A DNA mapping panel derived from an interspecific backcross was used to position the mouse insulin-2...
A DNA mapp ing pane l der ived f rom an in terspec i f i c backcross was used to pos i t ion the mou...
This report describes the development of obesity syndromes in mice caused by two autosomal recessive...
Previously, we identified a locus on 11p influencing obesity in families with type 2 diabetes. Based...
Previously, we identified a locus on 11p influencing obesity in families with type 2 diabetes. Based...
Diabetic animal models have made significant contributions to understanding the etiology of diabetes...
A mutation in the tub gene causes maturity-onset obesity, insulin resistance, and sensory deficits. ...
AbstractThe mutated gene responsible for the tubby obesity phenotype has been identified by position...
Studies of twins, adopted children, and some human populations indicate that there is a substantial ...
The peptide hormone, insulin-like growth factor I (IGF-I), is a major determinant of growth in mamma...
Previously, we identified a locus on 11p influencing obesity in families with type 2 diabetes. Based...
Obesity is the main cause of type 2 diabetes, accounting for 90-95% of all diabetes cases in the US....
Tubby, an autosomal recessive mutation, mapping to mouse chromosome 7, was recently found to be the ...
The tubby gene family consists of four members, TUB, TULP1, TULP2 and TULP3, with unknown function. ...
<p>The top two QTLs are chromosome 2 (LOD = 6.5) and chromosome 19 (LOD = 5.4). We select these two ...
A DNA mapping panel derived from an interspecific backcross was used to position the mouse insulin-2...
A DNA mapp ing pane l der ived f rom an in terspec i f i c backcross was used to pos i t ion the mou...
This report describes the development of obesity syndromes in mice caused by two autosomal recessive...
Previously, we identified a locus on 11p influencing obesity in families with type 2 diabetes. Based...
Previously, we identified a locus on 11p influencing obesity in families with type 2 diabetes. Based...
Diabetic animal models have made significant contributions to understanding the etiology of diabetes...
A mutation in the tub gene causes maturity-onset obesity, insulin resistance, and sensory deficits. ...
AbstractThe mutated gene responsible for the tubby obesity phenotype has been identified by position...
Studies of twins, adopted children, and some human populations indicate that there is a substantial ...
The peptide hormone, insulin-like growth factor I (IGF-I), is a major determinant of growth in mamma...
Previously, we identified a locus on 11p influencing obesity in families with type 2 diabetes. Based...
Obesity is the main cause of type 2 diabetes, accounting for 90-95% of all diabetes cases in the US....
Tubby, an autosomal recessive mutation, mapping to mouse chromosome 7, was recently found to be the ...
The tubby gene family consists of four members, TUB, TULP1, TULP2 and TULP3, with unknown function. ...
<p>The top two QTLs are chromosome 2 (LOD = 6.5) and chromosome 19 (LOD = 5.4). We select these two ...