UJI TOKSISITAS SUB KRONIK EKSTRAK DAUN KEMBANG SUNGSANG (Gloriosa superba L.) TERHADAP FUNGSI GINJAL TIKUS PUTIH

Abstract. Kembang sungsang (Gloriosa superba L.) including families Colchicaceae, empirically this plant can be used to treat gout, diuretic, rheumatic and cultivated because of its use. All parts of this plant contain alkaloids called colchichin and gloriosin and most found on the tuber. From the results of previous research, the ethanol extract of leaves and flowers antihiperurisemia Breech is included in the class materials "Practically Non-Toxic." However, repeated administration may cause toxic effects on body organs. Test the effect of 70% ethanol extract of kembang sungsang leaves of kidney function in male and female white rats. There are 3 (three) doses of test materials which are: 32.25 mg, 21.5 mg and 14.35 mg/100 g bw., And as a control was distilled water. Test and control material was administered orally in accordance with a predetermined time is 45 days, 90 days and 104 days (recovery period for the largest dose) administration. Observation is done by sacrificing mice according to given deadlines. Results of blood biochemistry analysis showed that drug therapy for 45 days, to increase blood urea and creatinine, but the award of 90 and 104 days (recovery) decreased creatinine levels.Keywords: Toxicity, Kembang Sungsang, Gloriosa superba L. Kidney functio