AKTIVITAS ANTIMALARIA (IN VIVO) KOMBINASI BUAH SIRIH (Piper betle L), DAUN MIYANA (Plectranthus scutellarioides (L.) R. BR.) MADU DAN KUNING TELUR PADA MEN CIT YANG DIINFEKSI Plasmodium berghei

Malaria is a major public health problem in the world and developing countries in particular, causing an estimated 1-2 million deaths per year, an annual incidence of 300-500 million clinical cases and more than 2 billion people were at risk of infection from it. But it is also becoming more difficult to treat malaria due to the increasing drug resistance. Therefore, the need for alternative drugs is acute. This study aims at investigating the in vivo antiplasmodial activity of Piper betle L., fruit (buah sirih), Plectranthus scutellarioides (L.) R. BR., (daun miyana), honey and egg yolk combination. Methods: A rodent malaria parasite, Plasmodium berghei, was inoculated into Swiss albino mice. The mice were infected with Ixl05 parasites intraperitoneally. The Piper betle L., fruit (buah sirih), Plectranthus scutellarioides (L.) R. BR., (daun miyana), honey and egg yolk combination were combined and administered by an intra gastric tube daily for seven days starting from the day of parasite inoculation. The control groups received the same amount of solvent (vehicle) used to suspend each dose of the herbal drug. Chloroquine was used as a standard drug, administered through the same route. Results: Combination of Piper betle L., fruit (buah sirih), Plectranthus scutellarioides (L.) R. BR., (daun miyana), honey and egg yolk were observed to inhibit Plasomodium berghei parasitaemia in the Swiss albino mice 100 % on the sixth day. Conclusion: The study could partly confirm the claim in East Sulawesi traditional medicine that the Piper betle L., fruit (buah sirih), Plectranthus scutellarioides (L.) R. BR., (daun miyana), honey and egg yolk combination has therapeutic values in human malaria. There was, thus, the need to initiate further in-depth investigation by using different experimental models