Add to ORKGCaenorhabditis elegans has become one of the premiere model systems for aging research due to their accessible genome and their ease of cultivation. Their genome is small compared to humans yet it encodes over 22,000 proteins; about 35% of C. elegans genes are closely related to human genes. The age-1 gene codes for phosphatidylinositol 3-kinase, which is part of a pathway that regulates longevity. An RNAi feeding vector was created to silence the age-1 gene. My hypothesis is that the lifespan of the treated nematodes will decrease relative to the control. The effectiveness of my constructed RNAi feeding strain will be studied by performing lifespan assays
The biological mechanisms of aging have been studied in depth and prominent findings in this field p...
Introduction: Diet has a strong influence on aging and lifespan. Thus, understanding the mechanisms ...
Most of our knowledge about the regulation of aging comes from mutants originally isolated for other...
Over a century ago, the zoologist Emile Maupas first identified the nematode, Rhabditis elegans, in ...
Several investigators have generated long-lived nematode worms (Caenorhabditis elegans) in the past ...
We report a systematic RNAi longevity screen of 82 Caenorhabditis elegans genes selected based on or...
nuture (or a diet of E. coli)? The first genes extending lifespan were identified in the nematode Ca...
To date, many genes and pathways regulating lifespan have been identified in the nematode Caenorhabd...
Just as any organism, us humans are subjected to the process of ageing. As we grow older, it becomes...
Studies of aging in the nematode Caenorhabditis elegans have revealed a relationship between stress ...
The nematode worm Caenorhabditis elegans has become a model system for the analysis of the genetics ...
As a tool for measuring the aging process, life span has been invaluable in dissecting the genes tha...
Key discoveries in aging research have been made possible with the use of model organisms. Caenorhab...
RNA binding proteins control post-transcriptional aspects of gene regulation. While transcriptional ...
Abstract: Progress in aging research has identified genetic and environmental factors that regulate ...
The biological mechanisms of aging have been studied in depth and prominent findings in this field p...
Introduction: Diet has a strong influence on aging and lifespan. Thus, understanding the mechanisms ...
Most of our knowledge about the regulation of aging comes from mutants originally isolated for other...
Over a century ago, the zoologist Emile Maupas first identified the nematode, Rhabditis elegans, in ...
Several investigators have generated long-lived nematode worms (Caenorhabditis elegans) in the past ...
We report a systematic RNAi longevity screen of 82 Caenorhabditis elegans genes selected based on or...
nuture (or a diet of E. coli)? The first genes extending lifespan were identified in the nematode Ca...
To date, many genes and pathways regulating lifespan have been identified in the nematode Caenorhabd...
Just as any organism, us humans are subjected to the process of ageing. As we grow older, it becomes...
Studies of aging in the nematode Caenorhabditis elegans have revealed a relationship between stress ...
The nematode worm Caenorhabditis elegans has become a model system for the analysis of the genetics ...
As a tool for measuring the aging process, life span has been invaluable in dissecting the genes tha...
Key discoveries in aging research have been made possible with the use of model organisms. Caenorhab...
RNA binding proteins control post-transcriptional aspects of gene regulation. While transcriptional ...
Abstract: Progress in aging research has identified genetic and environmental factors that regulate ...
The biological mechanisms of aging have been studied in depth and prominent findings in this field p...
Introduction: Diet has a strong influence on aging and lifespan. Thus, understanding the mechanisms ...
Most of our knowledge about the regulation of aging comes from mutants originally isolated for other...