Doped silica fibre thermoluminescence measurements of radiation dose in the use of 223 Ra
- Bradley, David Andrew
- Sani, S.F. Abdul
- Shafiqah, A.S. Siti
- Collins, Sean M.
- Hugtenburg, Richard P.
- Rashid, Hairul Azhar Abdul
- Zulkepely, Nurul Najua
- Maah, Mohd Jamil
DOIAbstract
Using tailor-made sub-mm dimension doped-silica fibres, thermoluminescent dosimetric studies have been performed for α-emitting sources of 223RaCl2 (the basis of the Bayer Healthcare product Xofigo®). The use of 223RaCl2 in the palliative treatment of bone metastases resulting from late-stage castration-resistant prostate cancer focuses on its favourable uptake in metabolically active bone metastases. Such treatment benefits from the high linear energy transfer (LET) and associated short path length (<100 µm) of the α-particles emitted by 223Ra and its decay progeny. In seeking to provide for in vitro dosimetry of the α-particles originating from the 223Ra decay series, investigation has been made of the TL yield of various forms of Ge-dope...
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