Clinical question: How does implementation of a family‐based prevention program compare with no intervention or an adolescent‐based program provided only to prevent or reduce alcohol use in adolescents?

Family‐based prevention programs may have little to no effect on reducing alcohol use in adolescents, but clinical trial evidence is of low certainty. Clinical trials vary considerably both in type (universal, selective, indicated) and duration of family interventions and comparisons assessed. Subgroup analyses examining results by intervention type are generally consistent with the main results, except for small benefit of a universal family‐based intervention for reducing the volume of alcohol consumption. No RCTs assessed adverse effects of the interventions