Polypharmacology has expanded enormously over the last ten years, with several multitarget drugs (MTDs) already in the market. This Viewpoint provides a basis for a discussion about the critical need to develop MTDs in a more rationale and conscious way. A checklist to maximize success in polypharmacology is proposed
Introduction: Polypharmacology has emerged as an essential paradigm for modern drug discovery proces...
The dominant paradigm in drug discovery is the concept of designing maximally selective ligands to a...
ABSTRACT: In drug discovery and development, the conventional “single drug, single target ” concept ...
Polypharmacology has expanded enormously over the last ten years, with several multitarget drugs (MT...
Polypharmacology offers a model for the way drug discovery must evolve to develop therapies most sui...
At present, the legendary magic bullet, i.e., a drug with high potency and selectivity toward a spec...
Promising promiscuity: Guest editors Maria Laura Bolognesi and Andrea Cavalli set the stage for this...
none2Drug discovery has contributed greatly to advancing the life sciences and the wellbeing of soci...
With the advancement in medical science, pharmaceutical industry has come up with solutions to count...
Background: Polypharmacology, defined as the modulation of multiple proteins rather than a single ta...
Background: Polypharmacology, defined as the modulation of multiple proteins rather than a single ta...
How to design a ligand to bind multiple targets, rather than to a single target, is the focus of thi...
The article is an editorial; it forecast that a new life in medicinal chemistry can be represented b...
Polypharmacology, a new paradigm in drug discovery that focuses on multi-target drugs (MTDs), has po...
Introduction: Polypharmacology has emerged as an essential paradigm for modern drug discovery proces...
The dominant paradigm in drug discovery is the concept of designing maximally selective ligands to a...
ABSTRACT: In drug discovery and development, the conventional “single drug, single target ” concept ...
Polypharmacology has expanded enormously over the last ten years, with several multitarget drugs (MT...
Polypharmacology offers a model for the way drug discovery must evolve to develop therapies most sui...
At present, the legendary magic bullet, i.e., a drug with high potency and selectivity toward a spec...
Promising promiscuity: Guest editors Maria Laura Bolognesi and Andrea Cavalli set the stage for this...
none2Drug discovery has contributed greatly to advancing the life sciences and the wellbeing of soci...
With the advancement in medical science, pharmaceutical industry has come up with solutions to count...
Background: Polypharmacology, defined as the modulation of multiple proteins rather than a single ta...
Background: Polypharmacology, defined as the modulation of multiple proteins rather than a single ta...
How to design a ligand to bind multiple targets, rather than to a single target, is the focus of thi...
The article is an editorial; it forecast that a new life in medicinal chemistry can be represented b...
Polypharmacology, a new paradigm in drug discovery that focuses on multi-target drugs (MTDs), has po...
Introduction: Polypharmacology has emerged as an essential paradigm for modern drug discovery proces...
The dominant paradigm in drug discovery is the concept of designing maximally selective ligands to a...
ABSTRACT: In drug discovery and development, the conventional “single drug, single target ” concept ...
DOI
Add to ORKG